Effectiveness of a new rutin Cu(II) complex in the prevention of lipid peroxidation and hepatotoxicity in hypercholesterolemic rats
| Autor: | Eduardo Guimarães Vieira, Renata Gorjão, Cristina Eunice Okuyama, Susana Nogueira Diniz, Daniel Antonio de Oliveira, Ivair D. Gonçalves, Ana Maria da Costa Ferreira, André L. Rennó, Regina Mara Silva Pereira |
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| Rok vydání: | 2021 |
| Předmět: |
inorganic chemicals
Antioxidant Rutin medicine.medical_treatment Hypercholesterolemia Flavonoid Biophysics Inflammation Pharmacology Lipid peroxidation chemistry.chemical_compound Nutraceutical medicine Animals chemistry.chemical_classification Liver Diseases Cell Biology Malondialdehyde Rats Cholesterol chemistry Simvastatin Lipid Peroxidation Chemical and Drug Induced Liver Injury medicine.symptom Food Science medicine.drug |
| Zdroj: | Journal of Food Biochemistry. 46 |
| ISSN: | 1745-4514 0145-8884 |
| Popis: | A new rutin copper(II) complex (R-Cu2) was prepared and characterized by spectroscopic methods and elemental analysis. The effects of rutin and R-Cu2 were evaluated on the prevention of hypercholesterolemia in animals feed with high-cholesterol diet (HCD) for 8 weeks. The animals (n = 5) were neither fed with HCD nor treated (control group), or were treated with vehicle, 10 mg/kg simvastatin, rutin (16 and 160 μmol/kg), and R-Cu2 (16 and 160 μmol/kg) administered orally. Total cholesterol (TC) levels were significantly increased (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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