Concentration of nitric oxide products in bronchoalveolar fluid obtained from infants who develop chronic lung disease of prematurity

Autor: David E. G. Shuker, David Field, J. R. Vyas, Sailesh Kotecha, Andrew Currie
Rok vydání: 1999
Předmět:
Zdroj: Archives of Disease in Childhood - Fetal and Neonatal Edition. 81:F217-F220
ISSN: 1468-2052
1359-2998
Popis: AIMS—To determine if nitric oxide (NO) products (nitrate and nitrite) are increased in bronchoalveolar lavage (BAL) fluid obtained from infants who develop chronic lung disease of prematurity (CLD). METHODS—One hundred and thirty six serial bronchoalveolar lavages were performed on 37 ventilated infants (12 with CLD, 18 with respiratory distress syndrome (RDS), and seven control infants) who did not receive inhaled NO. RESULTS—During the first week of life nitrate concentration was between 25-31 µmol/l in all three groups. Thereafter, the concentration of BAL fluid nitrate decreased to 14 µmol/l and 5.5 µmol/l, respectively in the RDS and control groups by 14 days of age. In contrast, nitrate in the CLD infants remained constant until 28 days of age (31.3 µmol/l at day 14; p
Databáze: OpenAIRE