Concentration of nitric oxide products in bronchoalveolar fluid obtained from infants who develop chronic lung disease of prematurity
Autor: | David E. G. Shuker, David Field, J. R. Vyas, Sailesh Kotecha, Andrew Currie |
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Rok vydání: | 1999 |
Předmět: |
Lung Diseases
Male Pathology medicine.medical_specialty Nitric Oxide Gastroenterology Nitric oxide chemistry.chemical_compound Nitrate Internal medicine medicine Humans Nitrite medicine.diagnostic_test Respiratory distress business.industry Respiratory disease Infant Newborn Obstetrics and Gynecology Original Articles General Medicine respiratory system medicine.disease Pathophysiology Bronchodilator Agents respiratory tract diseases Bronchoalveolar lavage chemistry Bronchopulmonary dysplasia Chronic Disease Pediatrics Perinatology and Child Health Female business Bronchoalveolar Lavage Fluid Infant Premature |
Zdroj: | Archives of Disease in Childhood - Fetal and Neonatal Edition. 81:F217-F220 |
ISSN: | 1468-2052 1359-2998 |
Popis: | AIMS—To determine if nitric oxide (NO) products (nitrate and nitrite) are increased in bronchoalveolar lavage (BAL) fluid obtained from infants who develop chronic lung disease of prematurity (CLD). METHODS—One hundred and thirty six serial bronchoalveolar lavages were performed on 37 ventilated infants (12 with CLD, 18 with respiratory distress syndrome (RDS), and seven control infants) who did not receive inhaled NO. RESULTS—During the first week of life nitrate concentration was between 25-31 µmol/l in all three groups. Thereafter, the concentration of BAL fluid nitrate decreased to 14 µmol/l and 5.5 µmol/l, respectively in the RDS and control groups by 14 days of age. In contrast, nitrate in the CLD infants remained constant until 28 days of age (31.3 µmol/l at day 14; p |
Databáze: | OpenAIRE |
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