Does Influenza Vaccination Modify Influenza Severity? Data on Older Adults Hospitalized With Influenza During the 2012-2013 Season in the United States

Autor: Lyn Finelli, Mary Lou Lindegren, William Schaffner, Ann Thomas, James Meek, Mary Hill, Evan J. Anderson, Joan Baumbach, Arthur Reingold, Elizabeth Mermel, Craig Morin, Susan Bohm, Krista Lung, Nancy M. Bennett, Carmen S. Arriola, Sandra S. Chaves, Oluwakemi Oni, Maya Monroe, Shelley M. Zansky, Lisa Miller
Rok vydání: 2015
Předmět:
Male
Aging
and promotion of well-being
Logistic regression
Severity of Illness Index
Medical and Health Sciences
law.invention
law
adults
Immunology and Allergy
Lung
Hazard ratio
Vaccination
virus diseases
Middle Aged
Biological Sciences
Intensive care unit
Hospitalization
Intensive Care Units
Infectious Diseases
3.4 Vaccines
Influenza Vaccines
Pneumonia & Influenza
Female
Seasons
Patient Safety
Infection
Human
medicine.medical_specialty
Influenza vaccine
macromolecular substances
Microbiology
Vaccine Related
Major Articles and Brief Reports
Internal medicine
medicine
Humans
Intensive care medicine
Aged
business.industry
Prevention
severe illness
Pneumonia
medicine.disease
Prevention of disease and conditions
Confidence interval
United States
Influenza
Logistic Models
Emerging Infectious Diseases
Propensity score matching
Immunization
influenza vaccine
business
Zdroj: The Journal of infectious diseases, vol 212, iss 8
Popis: Background. Some studies suggest that influenza vaccination might be protective against severe influenza outcomes in vaccinated persons who become infected. We used data from a large surveillance network to further investigate the effect of influenza vaccination on influenza severity in adults aged ≥50 years who were hospitalized with laboratory-confirmed influenza. Methods. We analyzed influenza vaccination and influenza severity using Influenza Hospitalization Surveillance Network (FluSurv-NET) data for the 2012−2013 influenza season. Intensive care unit (ICU) admission, death, diagnosis of pneumonia, and hospital and ICU lengths of stay served as measures of disease severity. Data were analyzed by multivariable logistic regression, parametric survival models, and propensity score matching (PSM). Results. Overall, no differences in severity were observed in the multivariable logistic regression model. Using PSM, adults aged 50−64 years (but not other age groups) who were vaccinated against influenza had a shorter length of ICU stay than those who were unvaccinated (hazard ratio for discharge, 1.84; 95% confidence interval, 1.12−3.01). Conclusions. Our findings show a modest effect of influenza vaccination on disease severity. Analysis of data from seasons with different predominant strains and higher estimates of vaccine effectiveness are needed.
Databáze: OpenAIRE
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