Role of muscarinic acetylcholine receptors in a guinea pig model of asthma
| Autor: | Yuji Tohda, Shigenori Nakajima, Ryuta Haraguchi, Hirokazu Kubo, Mari Itoh, Masahiro Fukuoka, Kentaroh Ohkawa |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Ovalbumin Immunology Guinea Pigs Nicotinic Antagonists Diamines Muscarinic Agonists Guinea pig Internal medicine Muscarinic acetylcholine receptor medicine Immunology and Allergy Animals Receptor Pharmacology Receptor Muscarinic M3 Receptor Muscarinic M2 Membranes biology Gallamine Triethiodide Chemistry Gallamine triethiodide Antagonist Pilocarpine Muscarinic acetylcholine receptor M3 Parasympatholytics respiratory system Receptors Muscarinic Asthma Endocrinology biology.protein medicine.drug |
| Zdroj: | International immunopharmacology. 2(11) |
| ISSN: | 1567-5769 |
| Popis: | We examined the density of muscarinic acetylcholine receptor (mACh-R) subtypes (M1R, M2R and M3R) in guinea pig lung. The density of M3R in the lung tissue of ovalbumin (OA)-sensitized guinea pigs was higher than that in the control group. However, no difference was observed in the affinity of M3R between the sensitized and the control lungs. No difference was observed in the density and affinity of M1R and M2R in sensitized and control lungs. Pilocarpine, which is an M2R stimulant, increased the density of M3R in the lung tissue and the rate of the increase in sensitized guinea pigs was less than that in the control group. In contrast, methoctranine, which is an M2R antagonist, decreased the density of M3R and the rate of this decrease was the same in the sensitized and control groups. These results suggest that, in OA-sensitized guinea pigs, a dysfunction of M2R leads to the abnormal density of M3R. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect