'Elephant-trunk' negative pressure wound therapy for fixing artificial dermis with basic fibroblast growth factor for critical limb ischemia
| Autor: | Nagisa Osa, Hiroyuki Sakurai, Kan Nakamoto, Wataru Kamei, Yosuke Niimi, Keijiro Hori |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Elephant trunks medicine.medical_treatment Basic fibroblast growth factor Biomedical Engineering Case Report Biomaterials chemistry.chemical_compound R5-920 Dermis Negative-pressure wound therapy Peripheral arterial disease medicine NPWT Fixation (histology) QH573-671 integumentary system business.industry Critical limb ischemia Negative pressure wound therapy Collagen-gelatin sponge Surgery medicine.anatomical_structure Amputation chemistry CLI Skin erosion medicine.symptom Cytology business Developmental Biology |
| Zdroj: | Regenerative Therapy Regenerative Therapy, Vol 18, Iss, Pp 316-320 (2021) |
| ISSN: | 2352-3204 |
| Popis: | Introduction The treatment of intractable toe ulcer with critical limb ischemia (CLI) is a challenge because of its poor blood flow and the wound. Here, a novel fixation technique for artificial dermis with negative pressure wound therapy (NPWT) was reported. Method After the amputation of toe, artificial dermis made of collagen-gelatin sponge (CGS) was grafted onto the wound where human recombinant basic fibroblast growth factor (bFGF) was sprayed. The foot was put on adhesive iodine-impregnated drape, the artificial-dermis area was covered with a sponge dressing of which another end reached to the drape, and the vacuum port was applied on the dressing sponge sandwiched with two drapes and connected to an NPWT system. Since the shape of sponge-dressing was similar to that of elephant-trunk, the technique in this study was named an “Elephant-trunk” technique. Result During NPWT period, no complications such as air leakage, skin erosion, ischemic around tissue were confirmed. The artificial dermis was engrafted completely at one week after surgery, and the wound was confirmed to close completely. Conclusion This NPWT technique with bFGF and CGS accelerated the healing of wound treated conservatively with artificial dermis in CLI patients. Highlights • A novel negative pressure wound therapy (NPWT) technique without any skin complications was developed. • NPWT technique in this study was effective for fixing artificial dermis made of collagen-gelatin sponge (CGS) in the critical limb ischemia (CLI). • NPWT with human basic fibroblast growth factor and CGS accelerated the healing of wound treated conservatively. |
| Databáze: | OpenAIRE |
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