iNOS promoter variants and severe malaria in Ghanaian children
| Autor: | Jana Burkhardt, Rowland N. Otchwemah, Ekkehardt Dietz, Jakob P. Cramer, Sabine Gellert, Ulrich Bienzle, Stephan Ehrhardt, Frank P. Mockenhaupt |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Linkage disequilibrium Genotype Population Nitric Oxide Synthase Type II Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Linkage Disequilibrium Nitric oxide chemistry.chemical_compound Gene Frequency parasitic diseases medicine Humans Genetic Predisposition to Disease education Child Promoter Regions Genetic education.field_of_study Haplotype Public Health Environmental and Occupational Health Infant Plasmodium falciparum medicine.disease biology.organism_classification Malaria Nitric oxide synthase Infectious Diseases chemistry Haplotypes Case-Control Studies Child Preschool Immunology biology.protein Parasitology Female Nitric Oxide Synthase Microsatellite Repeats |
| Zdroj: | Tropical medicineinternational health : TMIH. 9(10) |
| ISSN: | 1360-2276 |
| Popis: | Nitric oxide is an important mediator in the host defence against Plasmodium falciparum malaria. It has antiparasitic effects in vitro. However, its role in clinical disease remains controversial. Polymorphisms in the inducible nitric oxide synthase promoter (iNOS; -954G--C, -1173C--T, -2.6 kb CCTTT(n) microsatellite) may influence susceptibility to and severity of malaria. We tested this hypothesis in a case-control study among Ghanaian children with severe malaria (SM) and asymptomatic parasitaemia, respectively, and in healthy controls. In this study, the respective frequencies of iNOS-954G--C and -1173C--T did not differ between groups butor =13 microsatellite copies were associated with SM. -954G--C and -1173C--T were in linkage disequilibrium with CCTTT(8) and CCTTT(13), respectively. -954G--C/CCTTT(8) protected against hyperparasitaemia whereas -1173C--T/CCTTT(13) increased fatality. These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children. |
| Databáze: | OpenAIRE |
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