Alcohol Causes a Fatty Pancreas. A Rat Model of Ethanol-Induced Pancreatic Steatosis
| Autor: | P. W. Colley, Jeremy S. Wilson, Ron Pirola, L. Sosula, John B. Somer, B. A. Chapman |
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| Rok vydání: | 1982 |
| Předmět: |
medicine.medical_specialty
Calorie Medicine (miscellaneous) Alcohol Toxicology chemistry.chemical_compound Internal medicine medicine Animals Humans Pancreas Ethanol Cholesterol Pancreatic Diseases Rats Inbred Strains Carbohydrate Lipid Metabolism medicine.disease Rats Alcoholism Psychiatry and Mental health medicine.anatomical_structure Endocrinology chemistry Biochemistry Cholesteryl ester Female lipids (amino acids peptides and proteins) Cholesterol Esters Steatosis |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 6:117-121 |
| ISSN: | 1530-0277 0145-6008 |
| Popis: | To develop an animal model of alcoholic pancreatic steatosis, female Wistar rats were pair fed liquid diets, containing ethanol as 36% of calories or an isocaloric amount of carbohydrate for 3 weeks. Electron microscopic examination showed lipid vesicles localized principally at the bases of pancreatic acinar cells in the ethanol-fed rats. Ethanol feeding significantly increased pancreatic content of cholesteryl ester without changing levels of other lipids. Ethanol feeding enhanced labeled acetate, palmitate, oleate, and lino-leate incorporation into cholesteryl ester. Therefore, increased esterification of cholesterol may, in part, explain the observed accumulation of cholesteryl ester. |
| Databáze: | OpenAIRE |
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