In Vitro Modeling of Tumor-Immune System Interaction
| Autor: | Federica Foglietta, Manuele G. Muraro, Chantal Mengus, Giulio C. Spagnoli, Simone Muenst, Celeste Manfredonia, Valentina Mele, Giandomenica Iezzi, Francesca Amicarella, Savas D. Soysal |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Cell Biomedical Engineering Context (language use) Biology Biomaterials 03 medical and health sciences Immune system In vivo three-dimensional cultures tumor engineering tumor infiltrating cells tumor microenvironment tumor-immune cell interaction medicine Tumor microenvironment Innate immune system Cancer Immunotherapy medicine.disease 3. Good health 030104 developmental biology medicine.anatomical_structure Immunology Cancer research |
| Zdroj: | ACS biomaterials scienceengineering. 4(2) |
| ISSN: | 2373-9878 |
| Popis: | Immunotherapy has emerged during the past two decades as an innovative and successful form of cancer treatment. However, frequently, mechanisms of actions are still unclear, predictive markers are insufficiently characterized, and preclinical assays for innovative treatments are poorly reliable. In this context, the analysis of tumor/immune system interaction plays key roles, but may be unreliably mirrored by in vivo experimental models and standard bidimensional culture systems. Tridimensional cultures of tumor cells have been developed to bridge the gap between in vitro and in vivo systems. Interestingly, defined aspects of the interaction of cells from adaptive and innate immune systems and tumor cells may also be mirrored by 3D cultures. Here we review in vitro models of cancer/immune cell interaction and we propose that updated technologies might help develop innovative treatments, identify biologicals of potential clinical relevance, and select patients eligible for immunotherapy treatments. |
| Databáze: | OpenAIRE |
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