HIV-coinfection leads to a modest increase in plasma HCV-RNA load in patients with chronic HCV infection
| Autor: | José A. Mira, Manuel Parra-Sánchez, María J Vázquez, Jose C. Palomares, Federico A. Di Lello, Nicolás Merchante, Celia Cifuentes, Juan A. Pineda, Juan Macías, Silvia García-Rey, Karin Neukam |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Hepatitis C virus Human immunodeficiency virus (HIV) HIV Infections Hepacivirus medicine.disease_cause chemistry.chemical_compound Interquartile range Pegylated interferon Virology medicine Humans In patient Retrospective Studies Pharmacology HIV Coinfection business.industry Ribavirin virus diseases RNA Hepatitis C Chronic Middle Aged Viral Load chemistry RNA Viral Female business medicine.drug |
| Zdroj: | Antiviral Research. 95:212-215 |
| ISSN: | 0166-3542 |
| Popis: | The influence of HIV coinfection on plasma hepatitis C virus (HCV) RNA load has not been reliably evaluated. We analyzed plasma HCV RNA load in 396 HCV-monoinfected and 467 HIV/HCV-coinfected patients. Median HCV RNA concentrations (interquartile range) in HCV-monoinfected patients were 5.88 (5.3–6.2) log 10 IU/mL versus 5.96 (5.6–6.5) log 10 IU/mL in HIV/HCV-coinfected individuals ( p = 0.033) as determined with the Cobas Amplicor Test and 6.06 (5.4–5.7) log 10 IU/mL versus 6.3 (5.5–6.9) log 10 IU/mL ( p = 0.026) using the Cobas TaqMan System. The plasma HCV RNA load in patients with HIV infection and undetectable plasmatic HIV RNA was similar to that observed in HCV-monoinfected individuals [6.02 (5.45–6.61) log 10 IU/mL versus 6.01 (5.36–6.59) log 10 IU/mL, respectively ( p = 1.0)]. In conclusion, HIV coinfection tends to be associated with higher plasma HCV RNA load, however, the magnitude of the differences is small and this effect can be counterbalanced with antiviral therapy. |
| Databáze: | OpenAIRE |
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