Effects of tetra hydro cannabinol to the dendritc tree and synapses of the accumbens nucleus of wistar rats
| Autor: | S. Anđelić, S. Janković, Dubravka Aleksić, Branko Filipović, Gordana Stankovic, Milan Aksić, Lazar Stijak, Ivan Dimitrijevic, Nina Dimitrijević |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Synaptic cleft septal region Hippocampus Neurotransmission Nucleus accumbens 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine shell of accumbens nucleus Internal medicine medicine Tetrahydrocannabinol 030304 developmental biology 0303 health sciences lcsh:Veterinary medicine General Veterinary Chemistry Glutamate receptor Cannabis sativa 3. Good health Motor coordination axodendric synapse Endocrinology Anesthesia Cannabinol lcsh:SF600-1100 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Acta veterinaria (2013) 63(1):37-44 Acta Veterinaria, Vol 63, Iss 1, Pp 37-44 (2013) |
| ISSN: | 1820-7448 0567-8315 |
| Popis: | Cannabis is one of the most widely used intoxicants; almost half of all 18 year olds in the USA and in most European countries admit to having tried it at least once, and ~10% of that age group are regular users. Δ9-Tetrahydrocannabinol (THC), the principal psychoactive ingredient in marijuana, produces euphoria and relaxation and impairs motor coordination, time sense, and short term memory. In the hippocampus, CBs inhibit GABA release from a subset of interneurons and inhibit glutamate release from principal neurons. Cannabinoids are reported to produce both rapid and long-term changes in synaptic transmission. Our study was carried out on ten male rats out of which brains of six of them were used as the representative sample for electron microscope analysis, while 4 were used for light microspcopy performed by Golgi method. Three were exposed to THC and 3 were controls. Axodendric synapses in the core and shell of the accumbens nucleus (AN) were studied under electron microscope. The results have shown widening of the synaptic cleft in the shell of AN. This result is a leading point to our further investigations which are going to involve a behavioral component, and different aspects of morphological studies. [Projekat Ministarstva nauke Republike Srbije, br. III 41020] |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|