Hallmarks of primary neurulation are conserved in the zebrafish forebrain
| Autor: | Jonathan M. Werner, Allyson R. Caldwell, Jafira M. Johnson, Rachel Brewster, Maraki Y. Negesse, Dominique L. Brooks |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Neural Tube
Cell biology Neural fold formation Time Factors animal structures QH301-705.5 Recombinant Fusion Proteins Medicine (miscellaneous) Hindbrain Biology Time-Lapse Imaging General Biochemistry Genetics and Molecular Biology Article Animals Genetically Modified 03 medical and health sciences 0302 clinical medicine Prosencephalon Cell Movement medicine Morphogenesis Animals Neural Tube Defects Biology (General) Zebrafish Cell Shape Neurulation 030304 developmental biology Homeodomain Proteins 0303 health sciences Neural fold Neural Plate fungi Neural tube Epithelial Cells biology.organism_classification Luminescent Proteins medicine.anatomical_structure Forebrain embryonic structures General Agricultural and Biological Sciences Neuroscience Neural plate 030217 neurology & neurosurgery Transcription Factors |
| Zdroj: | Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021) Communications Biology |
| ISSN: | 2399-3642 |
| Popis: | Primary neurulation is the process by which the neural tube, the central nervous system precursor, is formed from the neural plate. Incomplete neural tube closure occurs frequently, yet underlying causes remain poorly understood. Developmental studies in amniotes and amphibians have identified hingepoint and neural fold formation as key morphogenetic events and hallmarks of primary neurulation, the disruption of which causes neural tube defects. In contrast, the mode of neurulation in teleosts has remained highly debated. Teleosts are thought to have evolved a unique mode of neurulation, whereby the neural plate infolds in absence of hingepoints and neural folds, at least in the hindbrain/trunk where it has been studied. Using high-resolution imaging and time-lapse microscopy, we show here the presence of these morphological landmarks in the zebrafish anterior neural plate. These results reveal similarities between neurulation in teleosts and other vertebrates and hence the suitability of zebrafish to understand human neurulation. Jonathan Werner, Maraki Negesse et al. visualize zebrafish neurulation during development to determine whether hallmarks of neural tube formation in other vertebrates also apply to zebrafish. They find that neural tube formation in the forebrain shares features such as hingepoints and neural folds with other vertebrates, demonstrating the strength of the zebrafish model for understanding human neurulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |