Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort:A Nationwide Study
| Autor: | Liselotte Petersen, Merete Nordentoft, Annette Erlangsen, Michael E. Benros, Teodor T. Postolache, Helene Gjervig Hansen, Ole Köhler-Forsberg |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty MOOD DISORDERS Denmark Infections AUTOIMMUNE-DISEASES Deliberate self-harm GONDII ANTIBODY-TITERS Danish Cohort Studies Primary care sector 03 medical and health sciences 0302 clinical medicine Anti-Infective Agents Risk Factors SCHIZOPHRENIA HISTORY Medicine Humans Registries Biological Psychiatry METAANALYSIS Proportional Hazards Models INFLAMMATORY CYTOKINES Inflammation business.industry Hazard ratio ASSOCIATION DEPRESSION Calendar period language.human_language C-REACTIVE PROTEIN Suicide 030104 developmental biology Increased risk Suicidal behavior Cohort language Anti-infective agents Female business Self-Injurious Behavior 030217 neurology & neurosurgery |
| Zdroj: | Gjervig Hansen, H, Köhler-Forsberg, O, Petersen, L, Nordentoft, M, Postolache, T T, Erlangsen, A & Benros, M E 2019, ' Infections, Anti-infective Agents, and Risk of Deliberate Self-harm and Suicide in a Young Cohort : A Nationwide Study ', Biological Psychiatry, vol. 85, no. 9, pp. 744-751 . https://doi.org/10.1016/j.biopsych.2018.11.008 |
| Popis: | BACKGROUND: Evidence links infections to mental disorders and suicidal behavior. However, knowledge is sparse regarding less severe infections, anti-infective treatment, and deliberate self-harm. Using nationwide Danish longitudinal registers, we estimated associations between infections treated with anti-infective agents and infections requiring hospitalization with the risk of deliberate self-harm.METHODS: A total of 1.3 million people born between 1977 and 2002 were followed during the period from 1995 to 2013. In total, 15,042 individuals were recorded with deliberate self-harm (92% had been treated with anti-infective agents and 19% had been hospitalized for infections) and 114 died by suicide (64% had been treated with anti-infective agents and 13% had been hospitalized for infections). Hazard rate ratios were obtained while adjusting for age, gender, calendar period, education, hospitalizations with infections, prescribed anti-infective agents during childhood, parental mental disorders, and parental deliberate self-harm.RESULTS: Individuals with infections treated with anti-infective agents had an increased risk of deliberate self-harm with a hazard rate ratio of 1.80 (95% confidence interval = 1.68-1.91). The associations fitted a dose-response relationship (p < .001) and remained significant up to 5 years after last infection. An additive effect was found for individuals with an additional hospitalization for infections with an increased hazard rate ratio of 3.20 (95% confidence interval = 2.96-3.45) for deliberate self-harm.CONCLUSIONS: An increased risk of deliberate self-harm was found among individuals with infections treated with anti-infective agents in temporal and dose-response associations. These results add to the growing literature on a possible link between infections and the pathophysiological mechanisms of suicidal behavior. |
| Databáze: | OpenAIRE |
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