Serum metastasin mRNA is an important survival predictor in breast cancer
| Autor: | El-Kwisky F, Zaki S, Sobhi A, Fahmy L, Faid W, Kandil K, Rasha A. El-Tahan, Eman El-Abd |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Genetic Markers Microbiology (medical) Oncology medicine.medical_specialty Pathology Adolescent Paget's Disease Mammary Clinical Biochemistry Immunology Breast Neoplasms Kaplan-Meier Estimate Metastasin Sensitivity and Specificity Microbiology Statistics Nonparametric Breast Diseases Young Adult Breast cancer Internal medicine medicine Humans Immunology and Allergy S100 Calcium-Binding Protein A4 Screening tool RNA Messenger Aged Messenger RNA business.industry S100 Proteins Biochemistry (medical) Significant difference Middle Aged Prognosis medicine.disease Survival Rate Carcinoma Lobular Carcinoma Intraductal Noninfiltrating Infectious Diseases Case-Control Studies Lymphatic Metastasis Female Lymph Breast carcinoma business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0967-4845 |
| DOI: | 10.1080/09674845.2008.11732804 |
| Popis: | This study investigates the possible prognostic role of serum metastasin messenger RNA (mRNA) in breast carcinoma as a non-invasive screening tool, and determines metastasin mRNA in the serum of breast cancer patients with high sensitivity (85%) and specificity (100%). A significant difference (P = 0.05) was observed between serum metastasin mRNA and the number of involved lymph nodes. Patients with higher expression of serum metastasin showed poor survival (six times worse) than those with lower levels. Patients negative for serum metastasin mRNA suffered recurrences, while those positive for serum metastasin mRNA suffered distant metastases. The results of this study suggest that serum metastasin mRNA represents an important survival marker in breast carcinoma. |
| Databáze: | OpenAIRE |
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