Upregulation of β3-adrenoceptors—a general marker of and protective mechanism against hypoxia?
Autor: | Bronwyn A Evans, Ebru Arioglu-Inan, Massimo Dal Monte, Martin C. Michel |
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Rok vydání: | 2019 |
Předmět: |
Congestive heart failure
β3-Adrenoceptor 0301 basic medicine Adrenergic receptor Rodent Biology 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Upregulation biology.animal medicine Homologous chromosome Hypoxia Gene Cancer Pharmacology Messenger RNA Diabetes General Medicine Hypoxia (medical) medicine.disease Cell biology 030104 developmental biology Heart failure medicine.symptom 030217 neurology & neurosurgery |
Zdroj: | Naunyn-Schmiedeberg's Archives of Pharmacology. 393:141-146 |
ISSN: | 1432-1912 0028-1298 |
Popis: | β3-Adrenoceptors exhibit a restricted expression pattern, particularly in humans. However, they have been found to be upregulated in various cancers and under several conditions associated with hypoperfusion such as congestive heart failure and diabetes for instance in the heart and other tissues. These conditions are frequently associated with hypoxia. Furthermore, direct induction of hypoxia has consistently been reported to cause upregulation of β3-adrenoceptors across various tissues of multiple species including humans, rats, dogs, and fish. While a canonical hypoxia-response element in the promoter of the human β3-adrenoceptor gene may play a role in this, no such sequence was found in rodent homologs. Moreover, not all upregulation of β3-adrenoceptor protein is accompanied by increased expression of corresponding mRNA, indicating that the upregulation may involve factors other than transcriptional changes. We propose that upregulation of β3-adrenoceptors at the mRNA and/or protein level is a general marker of hypoxic conditions. Moreover, it may be an additional pathway whereby cells and tissues adapt to reduced oxygen levels. |
Databáze: | OpenAIRE |
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