Quercetin, a Flavonoid Antioxidant, Ameliorated Procarbazine-Induced Oxidative Damage to Murine Tissues
| Autor: | Roseline Chinonye Echebiri, Ayokanmi Ore, Ebenezer Tunde Olayinka, Oluwatobi Adewumi Adeyemo, Olaoluwa Oluwaseun Olotu, Olaniyi Solomon Ola |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Antioxidant antioxidant Physiology Bilirubin medicine.medical_treatment Clinical Biochemistry medicine.disease_cause Biochemistry Article quercetin Superoxide dismutase chemistry.chemical_compound Internal medicine medicine oxidative stress rat Molecular Biology procarbazine biology lcsh:RM1-950 Cell Biology Glutathione Ascorbic acid Malondialdehyde lcsh:Therapeutics. Pharmacology Endocrinology chemistry biology.protein Quercetin Oxidative stress |
| Zdroj: | Antioxidants Volume 4 Issue 2 Pages 304-321 Antioxidants, Vol 4, Iss 2, Pp 304-321 (2015) |
| ISSN: | 2076-3921 |
| DOI: | 10.3390/antiox4020304 |
| Popis: | Procarbazine (PCZ) (indicated in Hodgkin’s disease), is an alkylating agent known to generate free radicals in vivo, while Quercetin (QCT) is a flavonoid antioxidant with proven free radical scavenging capacity. This study investigated the protective effects of QCT on PCZ-induced oxidative damage in the rat. Male Wistar rats (160–180 g) were randomized into five groups (n = 5/group): I (control), II PCZ-treated (2 mg/kg body weight (bw) for seven days) III pre-treated with QCT (20 mg/kg bw) for seven days, followed by PCZ for seven days IV co-treated with PCZ and QCT for seven days and V administered QCT alone for seven days. PCZ caused a significant increase in plasma total bilirubin, urea, and creatinine when compared with control (P < 0.05). Similarly, plasma activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GT) were significantly increased in the PCZ-treated group relative to control. Furthermore, PCZ caused a significant decrease in the activities of hepatic superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) as well as levels of ascorbic acid (AA) and glutathione (GSH). This was followed by a significant increase in hepatic malondialdehyde (MDA) content. However, QCT pre-treatment and co-treatment ameliorated the PCZ-induced changes in plasma levels of urea, creatinine, and bilirubin as well as the activities of ALP, AST, ALT, and GGT. QCT also ameliorated hepatic AA and GSH levels and the activities of SOD, CAT, and GST. This all suggests that QCT protected against PCZ-induced oxidative damage in rats. |
| Databáze: | OpenAIRE |
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