Acute effect of passive cycle-ergometry and functional electrical stimulation on nitrosative stress and inflammatory cytokines in mechanically ventilated critically ill patients: a randomized controlled trial

Autor: Adriano Flourencio Vilaça, C.M.M.B. De Castro, L A Forgiarini Júnior, U F Elihimas Júnior, Marcela Costa, Luana Carneiro Ribeiro, Maria do Amparo Andrade, M D S Paiva Júnior, Eduardo Eriko Tenório de França, Thamara Cunha Nascimento Amaral, J M B De Lira, J P V Gomes, M A V Correia Júnior
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Medicine (General)
Physiology
Stimulation
Nitrosative stress
Biochemistry
law.invention
Quadriceps Muscle
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
law
Biology (General)
General Pharmacology
Toxicology and Pharmaceutics
Physiotherapy
General Neuroscience
General Medicine
Middle Aged
Intensive care unit
Intensive Care Units
030220 oncology & carcinogenesis
Anesthesia
Cytokines
Female
medicine.symptom
Research Article
Adult
QH301-705.5
Critical Illness
Immunology
Biophysics
Ocean Engineering
Proinflammatory cytokine
Nitric oxide
03 medical and health sciences
R5-920
Intensive care
medicine
Functional electrical stimulation
Humans
Aged
Inflammation
business.industry
Motion Therapy
Continuous Passive
Muscle weakness
Cell Biology
Respiration
Artificial
Electric Stimulation
Oxidative Stress
030104 developmental biology
chemistry
business
Biomarkers
Zdroj: Brazilian Journal of Medical and Biological Research
Repositório Institucional do Centro Universitário La Salle
Universidade La Salle (UNILASALLE)
instacron:UNILASALLE
Brazilian Journal of Medical and Biological Research, Volume: 53, Issue: 4, Article number: e8770, Published: 09 APR 2020
Brazilian Journal of Medical and Biological Research v.53 n.4 2020
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
ISSN: 1414-431X
0100-879X
Popis: Early mobilization is beneficial for critically ill patients because it reduces muscle weakness acquired in intensive care units. The objective of this study was to assess the effect of functional electrical stimulation (FES) and passive cycle ergometry (PCE) on the nitrous stress and inflammatory cytometry in critically ill patients. This was a controlled, randomized, open clinical trial carried out in a 16-bed intensive care unit. The patients were randomized into four groups: Control group (n=10), did not undergo any therapeutic intervention during the study; PCE group (n=9), lower-limb PCE for 30 cycles/min for 20 min; FES group (n=9), electrical stimulation of quadriceps muscle for 20 min; and FES with PCE group (n=7), patients underwent PCE and FES, with their order determined randomly. The serum levels of nitric oxide, tumor necrosis factor alpha, interferon gamma, and interleukins 6 and 10 were analyzed before and after the intervention. There were no differences in clinical or demographic characteristics between the groups. The results revealed reduced nitric oxide concentrations one hour after using PCE (P
Databáze: OpenAIRE
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