The antioxidant effect of dexmedetomidine on testicular ischemia-reperfusion injury
| Autor: | Erdal Yilmaz, Pınar Atasoy, Ertan Batislam, Isin Yazici Gencay, Devrim Tuglu, Ucler Kisa, Ercan Yuvanc |
|---|---|
| Přispěvatelé: | Kırıkkale Üniversitesi |
| Rok vydání: | 2015 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Antioxidant Time Factors RD1-811 medicine.medical_treatment Ischemia Urology medicine.disease_cause Severity of Illness Index Antioxidants Random Allocation Reference Values Testis polycyclic compounds medicine Adrenergic alpha-2 Receptor Agonists Testicular torsion Animals Spermatic Cord Torsion Prospective Studies Dexmedetomidine Rats Wistar Prospective cohort study business.industry medicine.disease Immunohistochemistry Rats Oxidative Stress Anesthesia Reperfusion Injury Surgery business Reperfusion injury hormones hormone substitutes and hormone antagonists Oxidative stress medicine.drug |
| Zdroj: | Acta Cirúrgica Brasileira v.30 n.6 2015 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 30, Iss 6, Pp 414-421 (2015) Acta Cirurgica Brasileira, Volume: 30, Issue: 6, Pages: 414-421, Published: JUN 2015 |
| ISSN: | 1678-2674 |
| Popis: | KISA, Ucler/0000-0002-8131-6810; Batislam, Ertan/0000-0002-7493-4573 WOS: 000356828100007 PubMed: 26108030 PURPOSE: To investigate the protective effect of dexmedetomidine (Dex) on testicular damage induced by ischemia-reperfusion injury in rats. METHODS: Sham group underwent left scrotal exploration only (group 1). The ischemia-reperfusion only group underwent left testicular torsion and detorsion (group 2). The ischemia-reperfusion plus Dex group underwent left testicular torsion, received 50 mu g/kg Dex (group 3) and 100 mu g/kg Dex (group 4) intraperitoneally at minute 180 of ischemia and then underwent detorsion. We determined histopathological findings and performed specific biochemical analyses. RESULTS: Increasing doses of Dex significantly increased TAS, and significantly decreased OSI. Analyzing the antioxidant effects of increasing doses of Dex in torsion and contrlateral testicles: Dex 100 mu g/kg statistically significant increased the tissue total antioxidant status (TAS) and oxidative stress index (OSI) when compared with Dex 50 mu g/kg but not found significantly change on the tissue total oxidant status (TOS). However, Dex did not significantly improve these histological alterations. CONCLUSION: The antioxidant effects of dexmedetomidine on testicular ischemia-reperfusion injury in ipsilateral and contrlateral testis, but in the histopathological level, there was no difference statistically according to Johnsen's scoring system between groups at both sides. |
| Databáze: | OpenAIRE |
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