Potentiation of cocaine's discriminative effects by caffeine: A time-effect analysis
| Autor: | JoséR. Criado, Frank A. Holloway, David V. Gauvin, Kyle R. Moore |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Time effect Time Factors Stimulus generalization medicine.medical_treatment Clinical Biochemistry Effective time Pharmacology Stimulus (physiology) Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Discrimination Psychological Cocaine Caffeine medicine Animals Saline Biological Psychiatry Drug Synergism Rats Inbred Strains Long-term potentiation Drug interaction Rats Generalization Stimulus chemistry Psychology |
| Zdroj: | Pharmacology Biochemistry and Behavior. 36:195-197 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(90)90149-c |
| Popis: | The effects of caffeine upon the discriminative and rate-altering effects of cocaine were examined in rats. Using a food-reinforced two-lever operant procedure, 12 male Sprague-Dawley rats were trained to discriminate between 10 mg/kg cocaine and saline. Time-effect analysis of the training dose resulted in a median effective time interval (the duration of the discriminable effects of cocaine in producing 50% cocaine-appropriate responding), of 60.5 minutes postinjection. Caffeine partially generalized to the cocaine stimulus and, when administered with cocaine, produced a dose- and time-dependent increase in the percentage of drug-appropriate responding. Data are discussed with reference to our previous results with cocaine-caffeine interactions. |
| Databáze: | OpenAIRE |
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