Comparisons of heart-type fatty acid-binding protein (H-FABP) levels in off-pump versus on-pump coronary artery bypass grafting
| Autor: | Nilgun Kasifoglu, Orcun Unal, M. Behcet Sevin, Muhammet Fatih Yılmaz, Mustafa Ozer Ulukan, Murat Ugurlucan |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Aorta metabolic process off-pump fatty acid-binding globulin business.industry coronary artery bypass grafting General Medicine beating heart Group A Fatty acid-binding protein Group B Coronary artery bypass surgery medicine.anatomical_structure Clinical Research Heart-type fatty acid binding protein Internal medicine medicine.artery Cardiology Medicine Arterial blood lipids (amino acids peptides and proteins) business myocardial-specific Artery |
| Zdroj: | Archives of Medical Sciences. Atherosclerotic Diseases |
| ISSN: | 2451-0629 |
| DOI: | 10.5114/amsad.2019.85426 |
| Popis: | IntroductionHeart-type fatty acid-binding protein (H-FABP) is a novel indicator of myocardial damage. The aim of the study was to compare the levels of H-FABP in off-pump and on-pump coronary artery bypass grafting (CABG).Material and methodsThirty non-randomised 30 patients who underwent CABG between January 2009 and January 2010 were enrolled in the study. Patients were divided into two equal size (n = 15) groups as group A (off-pump CABG group) and group B (on-pump CABG group). Three arterial blood samples were obtained for H-FABP after sternotomy (H-FABP 1), after the last distal anastomosis in group A and immediately after the cross clamp was removed from the aorta in group B (H-FABP 2) and 24 h after the operation (H-FABP 3). Renal and liver functions and circulating fatty acid binding protein (FABP) levels were also assessed in blood samples obtained 24 h before and 1 h after the operation.ResultsAt all three assessment points patients in group B had significantly higher H-FABP values when compared with group A. Preoperative renal and liver functions were similar in both groups and they did not differ significantly in group A and group B when preoperative and postoperative values were compared. In both groups circulating FABP levels increased in the postoperative period, and the increase was more pronounced in the on-pump CABG group.ConclusionsOn-pump surgery resulted in higher levels of H-FABP as an ischaemic marker in patients receiving coronary artery bypass surgery. |
| Databáze: | OpenAIRE |
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