Restless Legs Syndrome and Drug-Induced Akathisia in Headache Patients
Autor: | William B. Young, Kevin M. Biglan, Elcio J Piovesan |
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Rok vydání: | 2003 |
Předmět: |
Adult
Male medicine.medical_specialty Adolescent Drug induced akathisia Iron Population Akathisia New daily persistent headache Chronic Migraine Restless Legs Syndrome Internal medicine mental disorders medicine Humans Restless legs syndrome education Orexins education.field_of_study business.industry Neuropeptides Headache Intracellular Signaling Peptides and Proteins medicine.disease Psychiatry and Mental health Dopamine receptor Ferritins Dopamine Antagonists Female Neurology (clinical) Headaches medicine.symptom Carrier Proteins business Akathisia Drug-Induced |
Zdroj: | CNS Spectrums. 8:450-456 |
ISSN: | 2165-6509 1092-8529 |
DOI: | 10.1017/s1092852900018769 |
Popis: | The purpose of the research presented in this article was to characterize restless legs syndrome (RLS) in a headache population and correlate treatment induced risks with dopamine blockers. Fifty patients with severe headache who were admitted to an outpatient infusion center were enrolled. The diagnosis of RLS was established using the International Restless Legs Syndrome Study Group criteria. Patients were screened for baseline akathisia using an akathisia scale and reexamined for akathisia after receiving intravenous infusion with one of four dopamine receptor blocking agents as treatment for their headaches. A change from baseline to post-infusion assessment of two points on a global assessment of akathisia was considered positive for drug-induced akathisia. Our results indicated that 41 (82%) of patients had episodic or chronic migraine. The rest had new daily persistent headache, cluster, or posttraumatic headache. Seventeen subjects (34%) met the criteria for RLS. Nineteen (38%) of the subjects developed drug-induced akathisia. Thirteen (76.5%) of the subjects with RLS developed akathisia compared with only 6 of the 33 (18.2%) without RLS (PFinally, we concluded that headache patients with RLS are at a greatly increased risk of developing drug-induced akathisia when treated with intravenous dopamine receptor blocking agents. |
Databáze: | OpenAIRE |
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