IL1HY1: A Novel Interleukin-1 Receptor Antagonist Gene
| Autor: | Deborah B. Loeb, Julio J. Mulero, Ann Pace, John E. Ford, Tanis R. Correa, Sarah T. Nelken, Radoje T. Drmanac |
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| Rok vydání: | 1999 |
| Předmět: |
Transcription
Genetic medicine.drug_class Sialoglycoproteins Molecular Sequence Data Biophysics Biology Biochemistry Cell Line Fetus Leukocytes medicine Humans Gene family 5-HT5A receptor Amino Acid Sequence RNA Messenger Receptor Molecular Biology Gene Gene Library Skin Base Sequence Sequence Homology Amino Acid Reverse Transcriptase Polymerase Chain Reaction Interleukins Macrophages Gene Amplification Interleukin-36 Brain Chromosome Mapping Proteins Receptors Interleukin-1 Interleukin Cell Biology Receptor antagonist Molecular biology Interleukin 1 Receptor Antagonist Protein Interleukin 1 receptor antagonist Organ Specificity Chromosomes Human Pair 2 Multigene Family Sequence Alignment Spleen |
| Zdroj: | Biochemical and Biophysical Research Communications. 263:702-706 |
| ISSN: | 0006-291X |
| DOI: | 10.1006/bbrc.1999.1440 |
| Popis: | Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide variety of physiological and cellular events. We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%. The gene was mapped to the long arm of chromosome 2, in close proximity to the IL-1 locus. IL1HY1 message is tightly regulated being most predominantly expressed in the skin, but also detected in the spleen, brain leukocyte, and macrophage cell types. Furthermore, the message can be induced in THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment. |
| Databáze: | OpenAIRE |
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