Resting state networks activity in euthymic bipolar disorder
| Autor: | Paolo Brambilla, Niccolò Zovetti, Marcella Bellani, Nicola Dusi, Cinzia Perlini, Elisa Ciceri, Pietro Bontempi, Veronica Marinelli, Letizia Squarcina, Giada Zoccatelli, Maria Gloria Rossetti, Andrea Sbarbati, Franco Alessandrini |
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| Rok vydání: | 2020 |
| Předmět: |
Cingulate cortex
Adult Male Bipolar Disorder Precuneus Dimensionality estimation Gyrus Cinguli 03 medical and health sciences Young Adult 0302 clinical medicine Cerebellum Parietal Lobe Medicine Humans Bipolar disorder Mri scan network analysis Biological Psychiatry Default mode network Brain Mapping Resting state fMRI business.industry Default Mode Network resting-state fMRI Brain Middle Aged medicine.disease Magnetic Resonance Imaging Cyclothymic Disorder 030227 psychiatry Psychiatry and Mental health Mood medicine.anatomical_structure Case-Control Studies Quality of Life Female business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Bipolar disordersReferences. 22(6) |
| ISSN: | 1399-5618 |
| Popis: | Objectives Bipolar disorder (BD) is a psychiatric condition causing shifts in mood, energy and activity levels severely altering the quality of life of the patients even in the euthymic phase. Although widely accepted, the neurobiological bases of the disorder in the euthymic phase remain elusive. This study aims at characterizing resting state functional activity of the BD euthymic phase in order to better understand the pathogenesis of the disease and build future neurobiological models. Methods Fifteen euthymic BD patients (10 females; mean age 40.2; standard deviation 13.5; range 20-61) and 27 healthy controls (HC) (21 females; mean age 37; standard deviation 10.6; range 22-60) underwent a 3T functional MRI scan at rest. Resting state activity was extracted through independent component analysis (ICA) run with automatic dimensionality estimation. Results ICA identified 22 resting state networks (RSNs). Within-network analysis revealed decreased connectivity in the visual, temporal, motor and cerebellar RSNs of BD patients vs HC. Between-network analysis showed increased connectivity between motor area and the default mode network (DMN) partially overlapping with the fronto-parietal network (FPN) in BD patients. Conclusion Within-network analysis confirmed existing evidence of altered cerebellar, temporal, motor and visual networks in BD. Increased connectivity between the DMN and the motor area network suggests the presence of alterations of the fronto-parietal regions, precuneus and cingulate cortex in the euthymic condition. These findings indicate that specific connectivity alterations might persist even in the euthymic state suggesting the importance of examining both within and between-network connectivity to achieve a global understanding of the BD euthymic condition. |
| Databáze: | OpenAIRE |
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