Synthesis, structure, and evaluation of a β-cyclodextrin-artificial carbohydrate conjugate for use as a doxorubicin-carrying molecule
| Autor: | Toshiyuki Inazu, Takashi Yamanoi, Yoshiki Oda, Kaname Katsuraya, Kenjiro Hattori |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
ドラッグキャリア
Drug carrier Stereochemistry Clinical Biochemistry Stacking Carbohydrates Pharmaceutical Science Conjugated system 010402 general chemistry Ring (chemistry) 01 natural sciences Biochemistry chemistry.chemical_compound Drug Discovery polycyclic compounds Molecule Cyclodextrin Benzene Molecular Biology Conjugate with a carbohydrate chemistry.chemical_classification Stacking complex シクロデキストリン Drug Carriers Molecular Structure 010405 organic chemistry Chemistry ドキソルビシン Organic Chemistry beta-Cyclodextrins NMR 0104 chemical sciences Doxorubicin Molecular Medicine 糖結合体 Derivative (chemistry) Conjugate |
| Zdroj: | Bioorganic & Medicinal Chemistry. 24(4):635-642 |
| ISSN: | 0968-0896 |
| Popis: | This paper describes the synthesis of a β-cyclodextrin (β-CyD) derivative conjugated with a C,C-glucopyranoside containing a benzene unit. Its doxorubicin-inclusion ability and structure are also discussed. SPR analysis revealed that the β-CyD conjugate had a high inclusion association value of 3.8×10(6)M(-1) for immobilized doxorubicin. NMR structural analysis suggested that its high doxorubicin-inclusion ability was due to the formation of the inclusion complex as a result of the π-π stacking interaction between the benzene ring of the conjugate and the A ring of doxorubicin. |
| Databáze: | OpenAIRE |
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