Common disbalance in the brain parenchyma of dementias: Phospholipid profile analysis between CADASIL and sporadic Alzheimer's disease
| Autor: | Andres Villegas-Lanau, Diego Sepulveda-Falla, Angélica Maria Sabogal-Guáqueta, Julián D. Arias-Londoño, Johanna Gutierrez-Vargas, Markus Glatzel, Gloria Patricia Cardona-Gómez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty CADASIL Leukoencephalopathy White matter 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cerebrospinal fluid Alzheimer Disease medicine Humans Dementia Gray Matter Least-Squares Analysis Molecular Biology Parenchymal Tissue Phospholipids Aged Aged 80 and over business.industry Discriminant Analysis Lysophosphatidylethanolamine Phosphatidylserine Middle Aged medicine.disease White Matter Frontal Lobe 030104 developmental biology medicine.anatomical_structure chemistry Case-Control Studies Multivariate Analysis Molecular Medicine Biomarker (medicine) Female Autopsy business Biomarkers 030217 neurology & neurosurgery |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1866:165797 |
| ISSN: | 0925-4439 |
| DOI: | 10.1016/j.bbadis.2020.165797 |
| Popis: | Sporadic Alzheimer's disease (SAD) is the most common form of dementia, and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent hereditary ischemic small vessel disease of the brain. Relevant biomarkers or specific metabolic signatures could provide powerful tools to manage these diseases. Therefore, the main goal of this study was to compare the postmortem frontal cortex gray matter, white matter and cerebrospinal fluid (CSF) between a cognitively healthy group and CADASIL and SAD groups. We evaluated 352 individual lipids, belonging to 13 lipid classes/subclasses, using mass spectrometry, and the lipid profiles were subjected to multivariate analysis to discriminate between the dementia groups (CADASIL and SAD) and healthy controls. The main lipid molecular species showing greater discrimination by partial least squares-discriminant analysis (PLS-DA) and a higher significance multivariate correlation (sMC) index were as follows: phosphatidylserine (PS) PS(44:7) and lysophosphatidylethanolamine (LPE) LPE(18:2) in gray matter (GM); phosphatidylethanolamine (PE) PE(32:2) and phosphatidylcholine PC PC(44:6) in white matter (WM), and ether PE (ePE) ePE(38:2) and ether PC (ePC) ePC(34:3) in CSF. Common phospholipid molecular species were obtained in both dementias, such as PS(44:7) and lyso PC (LPC) LPC(22:5) in GM, PE(32:2) in WM and phosphatidic acid (PA) PA(38:5) and PC(42:7) in CFS. Our exploratory study suggests that phospholipids (PLs) involved in neurotransmission alteration, connectivity impairment and inflammation response in GM, WM and CSF are a transversal phenomenon affecting dementias such as CADASIL and SAD independent of the etiopathogenesis, thus providing a possible common prodromal phospholipidic biomarker of dementia. |
| Databáze: | OpenAIRE |
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