Hepatitis C Virus universal screening versus risk based selective screening during pregnancy
| Autor: | Maroun J. Mhanna, Deepak Kumar, W. Waruingi, Nazha Abughali |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Hepatitis C virus Hepacivirus medicine.disease_cause Risk Assessment Sensitivity and Specificity 03 medical and health sciences Young Adult 0302 clinical medicine Inner city Pregnancy Risk Factors Surveys and Questionnaires medicine Prevalence Humans Mass Screening 030212 general & internal medicine Prospective Studies Pregnancy Complications Infectious Obstetrics business.industry Medical record Hepatitis C Antibodies medicine.disease Hepatitis C HCV Antibody Screening questionnaire Pediatrics Perinatology and Child Health 030211 gastroenterology & hepatology Observational study Female business |
| Zdroj: | Journal of neonatal-perinatal medicine. 8(4) |
| ISSN: | 1878-4429 |
| Popis: | OBJECTIVES We sought to compare the value of HCV universal screening versus risk-based selective screening in pregnant women. STUDY DESIGN In a prospective observational study (Jan 2012 - March 2012), pregnant women, in a high risk inner city clinic, who were at "low risk" for HCV infection were tested for HCV antibodies (universal screening) and their medical records were compared to the medical records of pregnant women who were at "high risk" (risk based selective screening as assessed by their obstetricians' screening questionnaire). RESULTS During the study period, 419 women delivered at our institution with 8.8% (37/419) at high risk for HCV. In 95% (183/193) of available and consenting low risk women, HCV antibody testing was done. The prevalence of HCV was 3.18% (7/220; 95% CI: 1.36-6.50) in all tested women versus 0.95% (4/419; 95% CI: 0.31-2.59) in risk-based selectively tested women. Overall the screening questionnaire had a sensitivity of 0.85 (0.42-0.99) and a specificity of 0.52 (0.45-0.58) in all women who had HCV antibody testing and questionnaire screening. CONCLUSIONS Using a screening questionnaire to identify women at risk for HCV infection during pregnancy under-estimates the real prevalence of HCV. A universal screening should be considered in high risk cities. |
| Databáze: | OpenAIRE |
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