Contact dependent suppression of CD4 T cell activation and proliferation by B cells activated through IgD cross-linking
| Autor: | Andrew W. Heath, James B. Wing, Robert C. Read, Rachel A. Foster, Lorena Preciado-Llanes, Jennifer Carlring, Andrew Lees |
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| Rok vydání: | 2014 |
| Předmět: |
CD40
biology Chemistry T cell ZAP70 Immunology chemical and pharmacologic phenomena Original Articles Natural killer T cell Molecular biology Cell biology Interleukin 21 medicine.anatomical_structure medicine biology.protein Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell |
| Zdroj: | Immunology. |
| ISSN: | 1365-2567 |
| Popis: | Although the co-stimulatory interaction between B and T cells is well defined, recent evidence suggests that B cells also have a regulatory role. Here, we show that B cells activated using anti-IgD conjugated to dextran (α-δ-dex) directly inhibit TCR-induced CD4 T cell activation, proliferation and cytokine production. This effect was observed in CD4 T cells activated both with and without CD28 co-stimulation. T cell viability was unaffected, and the T cell suppressive effect was mediated by contact with IgD activated purified B cells and not by IL-10 or other soluble factors. This is the first evidence of IgD activated B cells mediating inhibition of activation and proliferation of CD4 T cells in humans. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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