Real-life glycemic control in patients with type 2 diabetes treated with insulin therapy: A prospective, longitudinal cohort study (Diabetes Distress and Care Registry at Tenri [DDCRT 9])
| Autor: | Satoru Tsujii, Shintaro Okamura, Hitoshi Ishii, Naotaka Fujita, Yasuaki Hayashino, Miyuki Furuya, Tadao Iburi, Hirohito Kuwata, Shin Yamazaki, Nobuya Inagaki, Yosuke Yamamoto, Masako Kitatani, Shunichi Fukuhara |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Biphasic Insulins Type 2 diabetes Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine Humans Hypoglycemic Agents Insulin Longitudinal Studies Prospective Studies Registries 030212 general & internal medicine Aged Glycemic Glycated Hemoglobin business.industry Articles General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Insulin Long-Acting Regimen Clinical Science and Care Treatment Outcome Endocrinology Diabetes Mellitus Type 2 Insulin therapy Original Article Female Cohort study Insulin therepy business |
| Zdroj: | Journal of Diabetes Investigation |
| ISSN: | 2040-1116 |
| DOI: | 10.1111/jdi.12693 |
| Popis: | Aims/Introduction We investigated the association between four insulin regimens and increase in HbA1c and insulin dose in a real-life clinical setting because there is no data about them among insulin regimens. Materials and Methods Subjects included 757 patients with type 2 diabetes having been treated with insulin therapy for more than 1 year. The four insulin regimens were regimen 1 (long-acting insulin, once daily), regimen 2 (biphasic insulin, twice daily), regimen 3 (biphasic insulin, three times daily), and regimen 4 (basal-bolus therapy). Main outcomes were increases in HbA1c levels >0.5% and increases in daily insulin units after 1 year. We performed multivariable analyses to examine differences in glycemic control and insulin dose with adjustment for possible confounders. Results Mean HbA1c level and duration of insulin therapy were 7.8% and 11.3 years, respectively. HbA1c levels increased by >0.5% at follow-up in 22.8%, 24.9%, 20.7%, and 29.3% of subjects using regimen 1, 2, 3, and 4, respectively, with no significant differences between groups. Daily insulin doses increased in 62.3%, 68.8%, 65.3%, and 38.6% of patients, respectively (P |
| Databáze: | OpenAIRE |
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