Legume intake and risk of prostate cancer: a meta-analysis of prospective cohort studies
| Autor: | Jie Li, Qi-Qi Mao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Risk medicine.medical_specialty Veterinary medicine prostatic neoplasm Cohort Studies 03 medical and health sciences Prostate cancer 0302 clinical medicine Internal medicine Epidemiology medicine Humans 030212 general & internal medicine Prospective Studies Registries Prospective cohort study Legume business.industry Incidence (epidemiology) Incidence Prostatic Neoplasms Fabaceae legume medicine.disease Confidence interval Oncology 030220 oncology & carcinogenesis Meta-analysis Relative risk Population Surveillance Dietary Supplements epidemiology business Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Jie Li 1 and Qi-Qi Mao 2 1 Department of Urology, Lishui Central Hospital, The Fifth Affiliated Hospital, Wenzhou Medical University, Lishui, 323000, Zhejiang, China 2 Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China Correspondence to: Jie Li, email: lishuilijie2011@sina.com Keywords: legume, prostatic neoplasm, meta-analysis, epidemiology Received: February 21, 2017 Accepted: March 21, 2017 Published: April 03, 2017 ABSTRACT Previous studies regarding the relationship between legume intake and risk of prostate cancer have reported inconsistent results. We conducted a meta-analysis of prospective cohort studies to summarize evidence on this association. A systematic literature search of articles published through June 2016 was performed using PubMed and Web of Science databases. The combined relative risk (RR) with its 95% confidence interval (CI) for the highest versus the lowest intake of legumes was calculated with a random-effects model. Dose-response meta-analysis was also performed for the studies that provided at least three levels of legume consumption. Ten articles (eight cohorts) reporting 281,034 individuals and 10,234 incident cases were identified. The individuals with high consumption of legumes compared with the reference group experienced a significantly reduced risk for developing prostate cancer (RR: 0.85 [95% CI 0.75−0.96], P = 0.010). Moderate heterogeneity of RRs was observed across these studies ( P = 0.064 for heterogeneity, I 2 = 45.8 %). Dose-response meta-analysis indicated that the risk of prostate cancer reduced by 3.7% (95% CI 1.5%−5.8%) for each 20 grams per day increment of legume intake. In conclusion, the results from this meta-analysis suggest that a high intake of legumes is associated with a low incidence of prostate cancer. |
| Databáze: | OpenAIRE |
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