Sensory neurons control the functions of dendritic cells to guide allergic immunity
| Autor: | Caroline L. Sokol, Cameron H. Flayer |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
Innate immune system
Sensory Receptor Cells Neuropeptides Immunology Central nervous system Sensory system Dendritic Cells Dendritic cell Allergens Biology Acquired immune system Immunity Innate Article medicine.anatomical_structure Immune system Immunity Peripheral nervous system Hypersensitivity medicine Humans Immunology and Allergy Neuroscience |
| Zdroj: | Curr Opin Immunol |
| ISSN: | 0952-7915 |
| DOI: | 10.1016/j.coi.2021.10.009 |
| Popis: | Dendritic cells of the innate immune system and sensory neurons of the peripheral nervous system are embedded in barrier tissues and gather information about an organisms’ environment. While the mechanisms by which dendritic cells recognize and initiate adaptive immune responses to pathogens is well defined, how they sense allergens is poorly understood. Indeed, allergens induce dendritic cell maturation and migration in vivo, but not in vitro. How are adaptive immune responses to allergens initiated if dendritic cells do not directly sense allergens? Sensory neurons release neuropeptides within minutes of allergen exposure. Recent evidence demonstrated that while neuropeptides modify dendritic cell function during pathogen responses, they are required for dendritic cell function during allergic responses. These emerging studies suggest that sensory neurons do not just pass information along to the central nervous system, but also to dendritic cells, particularly during the initiation of adaptive immunity to allergens. |
| Databáze: | OpenAIRE |
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