Recombinant alpha-2 interferon gel treatment of recurrent herpes genitalis
| Autor: | David Fedorczyk, Mark Lebwohl, Jack Mendelson, Virginia Chen, L. J. Eron, J. Richard Trout, John M. Douglas, James D. Connor, Marcus A. Conant, Terry F. Plasse, Stephen L. Sacks, Steven Marlowe, Patricia Bradstreet |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Alpha interferon Administration Cutaneous Virus Replication Placebo Gastroenterology Double-Blind Method Recurrence Interferon Virology Internal medicine medicine Humans Viral shedding skin and connective tissue diseases Herpes Genitalis Interferon alfa Aged Pharmacology business.industry Middle Aged Recombinant Proteins Interferon Type I Immunology Itching Female Viral disease medicine.symptom business medicine.drug |
| Zdroj: | Antiviral Research. 17:235-243 |
| ISSN: | 0166-3542 |
| DOI: | 10.1016/0166-3542(92)90044-6 |
| Popis: | Topical recombinant alpha-2 interferon treatment of recurrent genital herpes was studied in a randomized, double-blind, placebo controlled clinical trial. Three hundred and eighty-seven patients were treated at eight study centers with either interferon gel or placebo four times daily for four days. Interferon therapy caused a 26% decrease in the duration of viral shedding. For male patients, there were also significant decreases in the time to crusting (17%) and duration of pain (34%) and itching (21%). For patients with recurrent genital herpes, treatment with topical interferon was found to be effective in decreasing the duration of viral shedding and, for males, pain, itching and time to crusting. |
| Databáze: | OpenAIRE |
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