HLA-B8, DR3: a new risk factor for graft failure after renal transplantation in patients with underlying immunoglobulin A nephropathy
| Autor: | Geert W. Haasnoot, Margret B. Andresdottir, Guido G. Persijn, Frans H.J. Claas |
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| Rok vydání: | 2009 |
| Předmět: |
Graft Rejection
Male medicine.medical_specialty Genotype Urinary system urologic and male genital diseases Gastroenterology HLA-B8 Antigen Risk Factors Internal medicine Immunopathology Epidemiology medicine Humans Registries Risk factor Receptors Tumor Necrosis Factor Member 25 Kidney transplantation Transplantation business.industry Haplotype Glomerulonephritis IGA Middle Aged Prognosis medicine.disease Kidney Transplantation Survival Rate Phenotype Treatment Outcome Haplotypes Immunology Female business Kidney disease |
| Zdroj: | Clinical Transplantation. 23:660-665 |
| ISSN: | 1399-0012 0902-0063 |
| Popis: | Background: The HLA-B8, DR3 haplotype has been associated with high immune reactivity. In this study, we have tested whether this haplotype has differential effect on graft survival in patients with IgAN compared with control patients. Methods: From the Eurotransplant Registry we analyzed graft survival of 1207 recipients with IgAN and 7935 control patients with non-glomerular diseases. Death-censored graft loss according to the HLA-B8, DR3 haplotype was calculated with Kaplan–Meier analysis and Cox-regression model was used to correct for various risk factors. Results: The frequency of the HLA-B8, DR3 haplotype was significantly lower in IgAN patients compared with controls (10.3% vs. 15.4%, p |
| Databáze: | OpenAIRE |
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