Clinical manifestations and course of meningococcal disease in 562 patients
| Autor: | Regina L. Schildkamp, Jacob Dankert, Rob J. P. M. Scholten, Mariette C. Lodder, Henk A. Bijlmer |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Pediatrics Adolescent Meningococcal disease Case fatality rate medicine Humans Risk factor Family history Child Aged Coma Aged 80 and over General Immunology and Microbiology business.industry Infant Newborn Infant General Medicine Middle Aged medicine.disease Surgery Meningococcal Infections Infectious Diseases Bacteremia Child Preschool Female medicine.symptom Complication business Meningitis |
| Zdroj: | Scandinavian journal of infectious diseases, 28(1), 47-51. Informa Healthcare |
| ISSN: | 0036-5548 |
| Popis: | To describe the clinical manifestations and course of meningococcal disease (MD) data were collected on patients with culture-proven MD, reported in the Netherlands between April 1, 1989 and April 30, 1990 by means of a questionnaire completed by the specialist in attendance. During the study period, 562 patients (295 males, 267 females) were reported. The age of the patients ranged from 2 weeks to 88 years. Of the patients, 57.8% were classified as meningitic, 20.3% as bacteraemic and 21.9% as both meningitic and bacteraemic. In 4.6% of the patients a predisposing factor was present, and in 1.4% a previous episode of meningitis had occurred. A positive family history of meningitis was reported in 12.9% of the patients. On admission, 65.2% of the patients had haemorrhagic skin lesions, 7.9% coma and 4.2% seizures. During admission, 17.8% of the patients developed serious complications. The fatality rate was 7.7%. In 73.2% of the deceased, death occurred within 2 days after admission. Of the survivors, 8.5% recovered with serious sequelae. In conclusion, 16% of the patients with meningococcal disease either died or became severely disabled. Prevention of this putative life-threatening disease seems to be the only means of circumventing the problems caused by this serious condition. |
| Databáze: | OpenAIRE |
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