Aging and immunoglobulin isotype patterns in oral tolerance
| Autor: | B. A. Verdolin, Ana Maria Caetano Faria, B. Stransky, J. S. Menezes, Nelson M. Vaz, Elaine Speziali, Virlânia Silva Rodrigues, Sabine Madsen Ficker, Lahmann Wm |
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| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Physiology
Immunoglobulin Isotypes Immunology Biophysics Biology Biochemistry Mice Antigen Immune Tolerance Animals General Pharmacology Toxicology and Pharmaceutics Oral tolerance mucosa lcsh:QH301-705.5 lcsh:R5-920 Mucous Membrane isotypes General Neuroscience oral tolerance aging Cell Biology General Medicine Antibody production Specific antibody lcsh:Biology (General) gut lcsh:Medicine (General) |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 31, Iss 1, Pp 35-48 (1998) Brazilian Journal of Medical and Biological Research, Volume: 31, Issue: 1, Pages: 35-48, Published: JAN 1998 Brazilian Journal of Medical and Biological Research v.31 n.1 1998 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Vol 31, Iss 1, p 35 (1998) |
| ISSN: | 0034-7310 |
| Popis: | In the present review we address oral tolerance as an importantbiological phenomenon and discuss how it is affected by aging. Otherfactors such as frequency of feeding and previous digestion of theantigen also seem to influence the establishment of oral tolerance. Wealso analyze immunoglobulin isotypes of specific antibodies formedby tolerant and immunized animals of different ages submitted todifferent conditions of oral antigen administration. Isotypic patternswere studied as a parameter for assessing the pathways of B and T cellinteractions leading to antibody production. Correspondence A.M.C. FariaDepartamento de Bioquimica eImunologia, ICB, UFMGAv. Antonio Carlos, 662731270-901 Belo Horizonte, MGBrasilPresented at the InternationalMeeting on Cytokines, Angra dosReis, RJ, Brasil, November 24-28,1996.Research supported by FAPEMIG(No. 2501/96), PRPq and CNPq(No. 53.0349/93-0).Received September 4, 1997Accepted November 6, 1997 Key words • Oral tolerance • Aging • Isotypes • |
| Databáze: | OpenAIRE |
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