Bioaccesibility, Metabolism, and Excretion of Lipids Composing Spent Coffee Grounds
| Autor: | Laura López-Gómez, Manuel Ignacio San Andres, Raquel Abalo, María Dolores del Castillo, Amaia Iriondo-DeHond, Fresia Santillan Cornejo, Eduardo Guisantes-Batan, S. Sánchez-Fortún, Beatriz Fernández-Gómez, J. A. Uranga, Gema Vera, Sergio Gomez Alonso |
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| Přispěvatelé: | Ministerio de Economía y Competitividad (España) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Animales de laboratorio Time Factors Cafestol Kahweol Coffea Pilot Projects Bioaccessibility Lipid liver biomarkers Feces chemistry.chemical_compound lipid metabolism Food science Biotransformation Nutrition and Dietetics Chemistry lipid liver biomarkers Fatty liver 04 agricultural and veterinary sciences 040401 food science spent coffee grounds Liver Seeds Toxicity lipids (amino acids peptides and proteins) Female Diterpenes lcsh:Nutrition. Foods and food supply medicine.drug Biological Availability lcsh:TX341-641 fatty acids Article Excretion kahweol 03 medical and health sciences 0404 agricultural biotechnology Intestinal Elimination medicine Animals Spent coffee grounds Rats Wistar Fatty acids 030109 nutrition & dietetics Lipid metabolism bioaccesibility medicine.disease lipid excretion Acute toxicity cafestol Steatosis Gastrointestinal Motility Lipid excretion Food Science |
| Zdroj: | Nutrients Volume 11 Issue 6 E-Prints Complutense. Archivo Institucional de la UCM instname Digital.CSIC. Repositorio Institucional del CSIC E-Prints Complutense: Archivo Institucional de la UCM Universidad Complutense de Madrid Nutrients, Vol 11, Iss 6, p 1411 (2019) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu11061411 |
| Popis: | This article belongs to the Special Issue Dietary Lipids and Human Health. The bioaccessibility, metabolism, and excretion of lipids composing spent coffee grounds (SCGs) were investigated. An analysis of mycotoxins and an acute toxicity study in rats were performed for safety evaluation. Total fat, fatty acids, and diterpenes (cafestol and kahweol) were determined in SCGs and their digests obtained in vitro. A pilot repeated intake study was carried out in Wistar rats using a dose of 1 g SCGs/kg b.w. for 28 days. Fat metabolism was evaluated by analysis of total fat, cholesterol, and histology in liver. The dietary fiber effect of SCGs was measured radiographically. The absence of mycotoxins and toxicity was reported in SCGs. A total of 77% of unsaturated fatty acids and low amounts of kahweol (7.09 µg/g) and cafestol (414.39 µg/g) were bioaccessible after in vitro digestion. A significantly lower (p < 0.1) accumulation of lipids in the liver and a higher excretion of these in feces was found in rats treated with SCGs for 28 days. No lipid droplets or liver damage were observed by histology. SCGs acutely accelerated intestinal motility in rats. SCGs might be considered a sustainable, safe, and healthy food ingredient with potential for preventing hepatic steatosis due to their effect as dietary fiber with a high fat-holding capacity. This research was funded by the SUSCOFFEE (AGL2014-57239-R) Project. |
| Databáze: | OpenAIRE |
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