Correlation of the local distribution of topically applied substances inside the stratum corneum determined by tape-stripping to differences in bioavailability
Autor: | Hans Schaefer, R. von Pelchrzim, Sabine Schanzer, Wolfram Sterry, H.-J. Weigmann, U Lindemann, Vinod P. Shah, Juergen Lademann |
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Rok vydání: | 2001 |
Předmět: |
Pharmacology
Clobetasol Chromatography Physiology Chemistry Blanching Administration Topical Biological Availability Dermatology General Medicine Absorption (skin) Stripping (fiber) Dosage form Bioavailability medicine.anatomical_structure Stratum corneum medicine Distribution (pharmacology) Humans Dermatologic Agents Clobetasol propionate Glucocorticoids Sunscreening Agents medicine.drug Skin |
Zdroj: | Skin pharmacology and applied skin physiology. 14 |
ISSN: | 1422-2868 |
Popis: | Tape-stripping and optical spectroscopy are used as a suitable combined method to determine the horny layer profile. Firstly, typical ultraviolet filter substances are used as active substances which are fixed inside the horny layer. Secondly, clobetasol propionate was applied topically in two formulations, Temovate® Cream and Temovate Ε Emollient®. The measured changes in the local distribution of the drug inside stratum corneum reflect the observed differences in the biological response visualized as blanching. The concentration of the drug in deeper parts of the horny layer proposes the existence of a small channel available for the percutaneous absorption. The observed low intensity blanching is correlated to the follicle orifices of the skin. After application of Temovate Ε Emollient®, a lateral spreading of the drug must be taken into account. |
Databáze: | OpenAIRE |
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