Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis

Autor:	Bent Deleuran, Oliver Hendricks, Holger Jon Møller, Line Dam Heftdal, Alice Christiansen, Bodil Arnbak, Anne Grethe Jurik, Stinne Ravn Greisen, Anne Gitte Loft, Berit Schiøttz-Christensen, René Østgård
Rok vydání:	2018
Předmět:	Male 0301 basic medicine Mannose-Binding Lectins/blood Clinical Biochemistry Anti-Inflammatory Agents receptors Gene Expression Anti-Inflammatory Agents/therapeutic use Receptors Cell Surface/blood Cohort Studies Macrophages/drug effects 0302 clinical medicine Cell Movement polycyclic compounds Soluble cd163 Axial spondyloarthritis skin and connective tissue diseases Receptor mannose receptor integumentary system Chemistry Lectins C-Type/blood food and beverages General Medicine Middle Aged macrophages spondylarthritis Female medicine.symptom Infiltration (medical) Mannose Receptor Mannose receptor Adult Antigens CD/blood Antigens Differentiation Myelomonocytic Receptors Cell Surface Inflammation 03 medical and health sciences Spondylarthritis/diagnosis Antigens CD Adalimumab/therapeutic use Spondylarthritis medicine Humans Lectins C-Type Sacroiliitis Antigens Differentiation Myelomonocytic/blood scavenger 030203 arthritis & rheumatology Sacroiliitis/diagnosis Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha/antagonists & inhibitors Macrophages Adalimumab biomarkers Cell movement Macrophage Activation medicine.disease Radiography Mannose-Binding Lectins Early Diagnosis 030104 developmental biology Solubility Cancer research CD163 Biomarkers Biomarkers/blood
Zdroj:	Heftdal, L D, Loft, A G, Hendricks, O, Ashouri Christiansen, A, Schiøttz-Christensen, B, Arnbak, B, Jurik, A G, Østgård, R, Winding Deleuran, B, Møller, H J & Greisen, S R 2018, ' Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 78, no. 6, pp. 483-489 . https://doi.org/10.1080/00365513.2018.1500704 Heftdal, L D, Loft, A G, Hendricks, O, Ashouri Christiansen, A, Schiøttz-Christensen, B, Arnbak, B, Jurik, A G, Østgård, R, Winding Deleuran, B, Møller, H J & Greisen, S R 2018, ' Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis ', Scandinavian Journal of Clnical and Laboratory Investigation, vol. 78, no. 6, pp. 483-489 . https://doi.org/10.1080/00365513.2018.1500704
ISSN:	1502-7686 0036-5513
DOI:	10.1080/00365513.2018.1500704
Popis:	The chronic joint inflammation in axial spondyloarthritis (axSpA) is characterized by infiltration of activated macrophages. The haptoglobin-hemoglobin receptor CD163 and the mannose receptor CD206 are strongly expressed on M2c and M2a macrophages, respectively. We measured the soluble forms of the receptors (sCD163 and sCD206) in plasma (PL) in two axSpA cohorts. All patients fulfil the 2009 Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axSpA and/or the 1984 modified New York criteria for ankylosing spondylitis. The first cohort included anti-TNF-α treated patients with active axSpA (n = 30); the second cohort included patients in early disease stages (n = 38). Plasma sCD163 and sCD206 were both within the reference interval of healthy controls (HC), but sCD163 decreased slightly during anti-TNF-α treatment [baseline: 1.49 mg/L (IQR: 1.22-1.77 mg/L, 12 weeks: 1.29 (IQR: 1.09-1.57) mg/L, 20 weeks: 1.25 (IQR: 0.99-1.75) mg/L, 52 weeks: 1.39 (IQR: 1.15-1.78) mg/L], while sCD206 increased [baseline: 0.17 (IQR: 0.13-0.21) mg/L, 12 weeks: 0.19 (0.16-0.23) mg/L, 20 weeks: 0.20 (0.14-0.24) mg/L, 52: 0.19 (IQR: 0.14-0.23) mg/L], pointing toward a shift in polarization of involved macrophages. Plasma levels of sCD206 proved significantly higher in patients with early disease stages and definite radiological sacroiliitis (n = 10). This was not the case for sCD163. A significant increase in response to anti-TNF-α treatment, could suggest sCD206 as a marker of response to anti-TNF-α treatment, however, the potential for the two macrophage markers as diagnostic and prognostic indicators of disease in axSpA is weak.
Databáze:	OpenAIRE
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