Randomized phase II placebo-controlled study to evaluate the efficacy of topical pure emu oil for joint pain related to adjuvant aromatase inhibitor use in postmenopausal women with early breast cancer: JUST (Joints Under Study)
| Autor: | Arlene Chan, Y. Zissiadis, D. Hastrich, Peter Willsher, A. Gan, R. De Boer, K. Miller, R. Martin, A. Bauwens |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Side effect medicine.drug_class Administration Topical Population Placebo-controlled study Breast Neoplasms Placebo 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine medicine Humans 030212 general & internal medicine Brief Pain Inventory education Adverse effect Adjuvants Pharmaceutic Neoplasm Staging education.field_of_study Aromatase inhibitor Aromatase Inhibitors business.industry Middle Aged Arthralgia Surgery Postmenopause Oncology 030220 oncology & carcinogenesis Joint pain Female medicine.symptom business Oils |
| Zdroj: | Supportive Care in Cancer. 25:3785-3791 |
| ISSN: | 1433-7339 0941-4355 |
| Popis: | Aromatase inhibitors are standard of care in women with hormone receptor-positive early breast cancer. Published evidence demonstrates that adverse effects may have an impact on drug compliance, with arthralgias being one of the most commonly reported adverse effects. Eligible patients were postmenopausal women who had experienced arthralgia following initiation of an aromatase inhibitor. Patients who experienced arthralgias following a minimum of a 3-month treatment on the aromatase inhibitor were randomized to emu oil or placebo oil. The primary endpoint was to assess for a reduction in pain as measured by a visual analogue score after 8 weeks of treatment. Seventy-three patients comprised the intent-to-treat population, and there was no statistically significant benefit with use of EO. However, there was a statistically significant improvement in pain (visual analogue score was −1.28; p |
| Databáze: | OpenAIRE |
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