The application of stem cell therapy and brown adipose tissue transplantation in metabolic disorders
| Autor: | Kang-Yun Lu, Shih Ping Liu, Shinn Zong Lin, Kingsley Theras Primus Dass, Horng-Jyh Harn |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Induced Pluripotent Stem Cells Immunology Adipose tissue White adipose tissue Exosomes 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Adipose Tissue Brown Metabolic Diseases Adipocyte Brown adipose tissue Animals Humans Immunology and Allergy Medicine Genetics (clinical) Transplantation business.industry Mesenchymal stem cell Cell Biology Stem-cell therapy Adipocytes Brown 030104 developmental biology medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis Cancer research Stem cell business Stem Cell Transplantation |
| Zdroj: | Cytotherapy. 22:521-528 |
| ISSN: | 1465-3249 |
| DOI: | 10.1016/j.jcyt.2020.06.004 |
| Popis: | The discovery of brown fat in adult humans has led to increased research of the thermogenic function of this tissue in various metabolic diseases. In addition, high levels of brown fat have been correlated with lower body mass index values. Therefore, increasing brown fat mass and/or activity through methods such as the browning of white fat is considered a promising strategy to prevent and treat obesity-associated diseases. Cell-based approaches using mesenchymal stromal cells and brown adipose tissue (BAT) have been utilized to directly increase BAT mass/activity through cell and tissue implantation into animals. In addition, recent studies evaluating the transplantation of human embryonic stem cells and induced pluripotent stem (iPS) cells have shown promising results in terms of positive metabolic function. In this comprehensive review, we provide a summary of the research over the past 10 years with regard to stem cell therapy and brown fat tissue transplantation for the effective treatment of metabolic syndrome. Recent advancements in stem cell methods have allowed for the production of brown adipocytes from human iPS cells, which represent an unlimited source of cellular material with which to study adipocyte development. In addition, this process is expected to be used to further explore drug- and cell-based therapies to treat obesity-related metabolic complications. |
| Databáze: | OpenAIRE |
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