Effects of glucagon-like peptide-I on glucose turnover in rats
| Autor: | JJ Holst, Anton B. Steffens, van Gertjan Dijk, S Lindskog, B Ahren |
|---|---|
| Přispěvatelé: | Van Dijk lab |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty insulin secretion fasting Physiology Metabolic Clearance Rate Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucagon-Like Peptides Incretin 7-36 AMIDE Biology Carbohydrate metabolism Glucagon INSULIN-SECRETION Eating HORMONE Glucagon-Like Peptide 1 HYPERGLYCEMIA Physiology (medical) Internal medicine medicine Animals Insulin Rats Wistar Pancreatic hormone PANCREAS Glucagon secretion tritiated glucose DIABETES-MELLITUS Metabolism Glucagon-like peptide-1 Peptide Fragments Rats Endocrinology Glucose INCRETIN glucagon secretion hormones hormone substitutes and hormone antagonists |
| Zdroj: | American Journal of Physiology, 270(6), E1015-E1021 Scopus-Elsevier CIÊNCIAVITAE Europe PubMed Central |
| ISSN: | 0002-9513 |
| Popis: | The influences of glucagon-like peptide-I-(7-36) amide (GLP-I; 15 pmol . kg(-1). min(-1)) on glucose turnover were studied in freely moving Wistar rats. In fed rats, GLP-I reduced plasma glucose (from 7.3 +/- 0.2 to 5.6 +/- 0.3 mmol/l; P = 0.017), increased plasma insulin (from 20 +/- 3 to 89 +/- 11 mU/l; P = 0.002), and reduced plasma glucagon (from 44 +/- 1 to 35 +/- 2 pg/ml; P = 0.009) and glucose appearance rate (R(a); from 3.9 1 0.2 to 1.7 +/- 0.7 mu mol . min(-1). 100 g(-1) after 30 min; P = 0.049) without affecting glucose disappearance rate (R(d)). The glucose clearance rate (MCR) was increased (P = 0.048). In 48-h-fasted rats, GLP-I reduced plasma glucose (from 5.0 +/- 0.2 to 4.4 +/- 0.3 mmol/l; P = 0.035) and increased plasma insulin (from 4 +/- 1 to 25 +/- 10 mU/l; P = 0.042) and plasma glucagon (from 43 +/- 3 to 61 +/- 7 pg/ml; P = 0.046). R(a) and R(d) were not significantly affected, although R(a) was lower than R(d) after 15-30 min (P = 0.005) and MCR was increased (P = 0.049). Thus GLP-I reduces R(a) in fed rats and increases MCR in fed and fasted rats. The reduced R(a) seems mediated by an increased insulin-to-glucagon ratio; the increased glucose clearance seems dependent on insulin and a peripheral effect of GLP-I. |
| Databáze: | OpenAIRE |
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