Spatial regionalization and heterochrony in the formation of adult pallial neural stem cells
| Autor: | Sonya Galant, Lara Dirian, Laure Bally-Cuif, Sébastien Bedu, Marion Coolen, Corinne Houart, Isabelle Foucher, Wenbiao Chen |
|---|---|
| Přispěvatelé: | Neurobiologie et Développement (N&eD), Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Department of Molecular Physiology and Biophysics, Vanderbilt University [Nashville], Centre for Developmental Neurobiology, King‘s College London |
| Rok vydání: | 2013 |
| Předmět: |
Transcription
Genetic Neurogenesis Population Subventricular zone Globus Pallidus General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Neural Stem Cells medicine Animals Cell Lineage education Promoter Regions Genetic Molecular Biology Zebrafish Embryonic Stem Cells 030304 developmental biology Neurons 0303 health sciences education.field_of_study biology Cerebrum Gene Expression Regulation Developmental Cell Biology Anatomy Zebrafish Proteins biology.organism_classification Embryonic stem cell Neural stem cell Neuroepithelial cell Adult Stem Cells medicine.anatomical_structure Organ Specificity [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neuroscience Neuroglia 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Cell Developmental Cell, Elsevier, 2014, 30 (2), pp.123-36. ⟨10.1016/j.devcel.2014.05.012⟩ |
| ISSN: | 1878-1551 1534-5807 |
| Popis: | International audience; Little is known on the embryonic origin and related heterogeneity of adult neural stem cells (aNSCs). We use conditional genetic tracing, activated in a global or mosaic fashion by cell type-specific promoters or focal laser uncaging, coupled with gene expression analyses and Notch invalidations, to address this issue in the zebrafish adult telencephalon. We report that the germinal zone of the adult pallium originates from two distinct subtypes of embryonic progenitors and integrates two modes of aNSC formation. Dorsomedial aNSCs derive from the amplification of actively neurogenic radial glia of the embryonic telencephalon. On the contrary, the lateral aNSC population is formed by stepwise addition at the pallial edge from a discrete neuroepithelial progenitor pool of the posterior telencephalic roof, activated at postembryonic stages and persisting lifelong. This dual origin of the pallial germinal zone allows the temporally organized building of pallial territories as a patchwork of juxtaposed compartments. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|