The closed eye harbors a unique microbiome in dry eye disease
Autor: | Amit Gaggar, Charitharth Vivek Lal, Kelly K. Nichols, Gabriel Rezonzew, Kent A. Willis, Cameron K Postnikoff, Amelia Freeman |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0303 health sciences
Future studies genetic structures business.industry Inflammation Disease eye diseases 3. Good health 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Immunology 030221 ophthalmology & optometry Medicine Tears Microbiome sense organs medicine.symptom business Ocular disease 030304 developmental biology Dry Eye Therapy Corneal epithelium |
DOI: | 10.1101/2020.01.08.20016865 |
Popis: | Dry eye affects millions of individuals. In experimental models, dry eye disease is associated with T helper cell 17-mediated inflammation of the ocular surface that may cause persistent damage to the corneal epithelium. However, the initiating and perpetuating factors associated with chronic inflammation of the ocular surface remain unclear. The ocular microbiota alters ocular surface inflammation and may influence dry eye disease development and progression. Here, we collected serial samples of closed eye tears during a randomized clinical trial of a non-pharmaceutical dry eye therapy and used 16S rRNA metabarcoding to characterize the microbiome. We show the closed dry eye microbiome is distinct from the healthy closed eye microbiome. The ocular microbiome was described only recently, and this report implicates a distinct microbiome in ocular disease development. Our findings suggest an interplay between microbial commensals and inflammation on the ocular surface. This information may inform future studies of the pathophysiological mechanisms of dry eye disease. |
Databáze: | OpenAIRE |
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