Viral etiology of severe acute respiratory infections in hospitalized children in Cameroon, 2011-2013
| Autor: | Suzie Moyo‐Tetang, Astrid Vabret, Mohamadou Njankouo-Ripa, Sebastien Kenmoe, Richard Njouom, Angeladine Kenne, Véronique Penlap Beng, Patrice Tchendjou, Marie-Astrid Vernet, Tatiana Mossus |
|---|---|
| Přispěvatelé: | Centre Pasteur du Cameroun, Réseau International des Instituts Pasteur (RIIP), Université de Yaoundé I, Service de Virologie [CHU Caen], CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Essos [Yaoundé, Cameroun], This work was funded by the International Network of Pasteur Institutes (PTR 351) and the 'Institut de Microbiologie et de Maladies Infectieuses (IMMI)' in France’., We are grateful to all the nurses and other healthcare workers who collected specimens, data, and information and provided their support with clinical evaluations of patients during this study. |
| Rok vydání: | 2016 |
| Předmět: |
MESH: Respiratory Tract Infections/epidemiology
MESH: Viruses/genetics 0301 basic medicine Male Rhinovirus Epidemiology viruses MESH: Viruses/classification MESH: Hospitalization medicine.disease_cause 0302 clinical medicine Cost of Illness MESH: Child MESH: Coinfection/virology Human bocavirus Nasopharynx Medicine MESH: Rhinovirus/isolation & purification MESH: Carrier State/epidemiology 030212 general & internal medicine Cameroon Prospective Studies Child Respiratory Tract Infections [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology MESH: Human bocavirus/genetics MESH: Multiplex Polymerase Chain Reaction Respiratory tract infections biology MESH: Viruses/isolation & purification Coinfection MESH: Respiratory Syncytial Virus Human/genetics virus diseases MESH: Rhinovirus/genetics MESH: Cost of Illness MESH: Infant 3. Good health MESH: Acute Disease/epidemiology Hospitalization Human Parainfluenza Virus Infectious Diseases Child Preschool [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Acute Disease Carrier State Epidemiological Monitoring Viruses MESH: Cameroon/epidemiology Female Original Article Seasons Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent etiology 030106 microbiology virus [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology 03 medical and health sciences MESH: Carrier State/virology Human metapneumovirus Internal medicine MESH: Nasopharynx/virology MESH: Respiratory Syncytial Virus Human/isolation & purification Humans MESH: Human bocavirus/isolation & purification severe acute respiratory infections MESH: Adolescent MESH: Humans business.industry MESH: Child Preschool Public Health Environmental and Occupational Health Infant Original Articles medicine.disease biology.organism_classification [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Virology MESH: Prospective Studies MESH: Male Respiratory Syncytial Virus Human Africa Etiology Enterovirus MESH: Epidemiological Monitoring business MESH: Seasons MESH: Female Multiplex Polymerase Chain Reaction MESH: Respiratory Tract Infections/virology |
| Zdroj: | Influenza and Other Respiratory Viruses Influenza and Other Respiratory Viruses, Wiley Open Access, 2016, 10 (5), pp.386-393. ⟨10.1111/irv.12391⟩ |
| ISSN: | 1750-2659 1750-2640 |
| DOI: | 10.1111/irv.12391⟩ |
| Popis: | International audience; BACKGROUND: Severe acute respiratory illness (SARI) is recognized as an important cause of morbidity, mortality, and hospitalization among children in developing countries. Little is known, however, in tropical countries like Cameroon about the cause and seasonality of respiratory infections, especially in hospitalized settings.OBJECTIVES: Our study investigates the viral etiology and seasonality of SARI in hospitalized children in Yaounde, Cameroon.METHODS: Prospective clinic surveillance was conducted to identify hospitalized children aged ≤15 years presenting with respiratory symptoms ≤5-day duration. Demographic and clinical data, and respiratory specimens were collected. Nasopharyngeal samples were tested for 17 respiratory viruses using a multiplex polymerase chain reaction. The viral distribution and demographic data were statistically analyzed.RESULTS: From September 2011 through September 2013, 347 children aged ≤15 years were enrolled. At least one virus was identified in each of 65·4% children, of which 29·5% were coinfections; 27·3% were positive for human adenovirus (hAdV), 13·2% for human respiratory syncytial virus (hRSV), 11·5% for rhinovirus/enterovirus (RV/EV), 10·6% for human bocavirus (hBoV), 9·8% for influenza virus (Inf), 6·6% for human parainfluenza virus (hPIV), 5·7% for human coronavirus (hCoV), and 2·3% for human metapneumovirus (hMPV). While hRSV showed seasonal patterns, hAdV and RV/EV were detected throughout the year and no evident temporal patterns were observed for the remaining viruses.CONCLUSION: Respiratory viruses were associated with a high burden of hospitalizations among children in Cameroon. Nevertheless, additional studies evaluating asymptomatic Cameroonian children will be important in understanding the relationship between viral carriage and disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |