Photothermal cancer therapy via femtosecond-laser-excited FePt nanoparticles
| Autor: | Yang-Yuan Chen, Chia Chun Chen, Yeukuang Hwu, Dzung Han Tsai, Shang-Wei Chou, Cheng-Lung Chen, Kung-Hsuan Lin, Shin Yu Lee, Fu Hsiung Chang, Ling Ru Kuo |
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| Rok vydání: | 2012 |
| Předmět: |
Materials science
Iron education Biophysics Nanoparticle Bioengineering Nanotechnology Radiation Dosage law.invention Biomaterials Mice law Cell Line Tumor Animals Low-Level Light Therapy Platinum Photothermal effect technology industry and agriculture Mammary Neoplasms Experimental Hyperthermia Induced Photothermal therapy equipment and supplies Laser Magnetic hyperthermia Treatment Outcome Mechanics of Materials Femtosecond Drug delivery Ceramics and Composites Nanoparticles Nanorod |
| Zdroj: | Biomaterials. 34(4) |
| ISSN: | 1878-5905 |
| Popis: | FePt nanoparticles (NPs) have recently been revealed to be significant multifunctional materials for the applications of biomedical imaging, drug delivery and magnetic hyperthermia due to their novel magnetic properties. In this study, a newly discovered photothermal effect activated by the near infrared (NIR) femtosecond laser for FePt NPs was demonstrated. The threshold laser energy to destroy cancer cells was found to be comparable to that of gold nanorods (Au NRs) previously reported. Through the thermal lens technique, it was concluded that the temperature of the FePt NPs can be heated up to a couple of hundreds degree C in picoseconds under laser irradiation due to the excellent photothermal transduction efficiency of FePt NPs. This finding boosts FePt NPs versatility in multifunctional targeted cancer therapy. |
| Databáze: | OpenAIRE |
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