Reasons to Reconsider Risk Associated With Power Morcellation of Uterine Fibroids
| Autor: | Wolfgang Kuepker, Carsten Holzmann, Burkhard Helmke, Joern Bullerdiek, Birgit Rommel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty Uterine fibroids medicine.medical_treatment Morcellation Review Article Malignancy General Biochemistry Genetics and Molecular Biology Malignant transformation 03 medical and health sciences 0302 clinical medicine Surgical removal Medicine Humans Retrospective Studies Pharmacology Hysterectomy Leiomyoma business.industry Uterus Nodule (medicine) medicine.disease 030220 oncology & carcinogenesis Smooth Muscle Tumor Uterine Neoplasms Female Radiology medicine.symptom business Risk assessment |
| Zdroj: | In vivo (Athens, Greece). 34(1) |
| ISSN: | 1791-7549 |
| Popis: | Our insights into the molecular pathogenesis of uterine smooth muscle tumors have improved significantly. Accordingly, in the present review, we advocate a more refined risk assessment for patients considering surgical removal of fibroids or hysterectomy, respectively, requiring morcellation. For this procedure, the risk estimates given for the iatrogenic spread of a previously unexpected malignancy considerably vary among different studies. Nearly all previous studies conducted retrospectively refer to the risk of a patient having an unexpected malignancy at the time of surgery. We feel that, more appropriately, risk should refer to the number of tumors because, as a rule, every single nodule arises independently and, thus, carries an independent risk of being malignant or not. Furthermore, whether so-called parasitic fibroids carry an underestimated risk of stepwise malignant transformation is discussed. |
| Databáze: | OpenAIRE |
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