Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis

Autor: Bedia Gülen, Omer Uysal, Orhan Kocaman, Kenan Ahmet Turkdogan, Mehmet Yigit, Elif Kilic, Ertan Sonmez, Siddika Keskin, Ali Dur, Abdurrahim Kocyigit
Přispěvatelé: UYSAL, ÖMER
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
DNA damage
Arbitrary unit
Lymphocyte
medicine.disease_cause
Severity of Illness Index
Gastroenterology
Antioxidants
03 medical and health sciences
0302 clinical medicine
Internal medicine
Severity of illness
medicine
Humans
Lymphocytes
Pancreas
DUR A.
KOCAMAN O.
Kocyigit A.
Turkdogan K. A.
Sonmez E.
KESKIN S.
YIGIT M.
Gulen B.
KILIC E.
Uysal O.
-Oxidative status and lymphocyte DNA damage in patients with acute pancreatitis and its relationship with severity of acute pancreatitis-
TURKISH JOURNAL OF GASTROENTEROLOGY
cilt.27
ss.68-72
2016
business.industry
Case-control study
Middle Aged
medicine.disease
Oxidative Stress
medicine.anatomical_structure
Pancreatitis
Case-Control Studies
030220 oncology & carcinogenesis
Acute Disease
Immunology
Acute pancreatitis
Female
030211 gastroenterology & hepatology
business
Oxidative stress
DNA Damage
Zdroj: The Turkish Journal of Gastroenterology. 27:68-72
ISSN: 2148-5607
1300-4948
Popis: BACKGROUND/AIMS Acute pancreatitis (AP) is a life-threatening disease with a rising incidence. The aim of this study was to investigate the association between oxidative status, lymphocyte deoxyribonucleic acid (DNA) damage, and acute pancreatitis. MATERIALS AND METHODS A total of 45 patients with AP and 35 healthy controls were included in the study. We assessed pancreatic enzymes, oxidative stress, and lymphocyte DNA damage. The severity of AP disease was determined by the Harmless Acute Pancreatitis Score (HAPS) and Balthazar scoring systems. RESULTS In AP patients, lymphocyte DNA damage was significantly higher than in controls [49.84±25.48 arbitrary units (AU) vs. 28.80±13.98 AU, p
Databáze: OpenAIRE
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