| Autor: |
AK, ESİN, OKTAY, NİHAL ŞEHKAR, ÖZBEYLİ, DİLEK, AK, KORAY |
| Přispěvatelé: |
AK E., OKTAY N. Ş., ÖZBEYLİ D., Muhan A., AK K. |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Southern Clinics of Istanbul Eurasia. |
| ISSN: |
2587-0998 |
| DOI: |
10.14744/scie.2022.57873 |
| Popis: |
Objective: Remote lung injury is one of the most challenging issues in patients undergoing ischemia reperfusion (IR) injury of the lower limbs. We examined the role of progesterone (PG) on the remote injury of the lungs seen after IR of the lower limbs. Methods: Eighteen male Sprague Dawley rats were divided into three groups. (1) Control: rats had only two physiological saline injections intraperitoneally (i.p.) 2 h apart under general anesthesia. (2) IR: underwent 2 h tourniquet induced ischemia for both lower limbs followed by 2 h of reperfusion. Animals were injected with physiological saline (i.p.) before both ischemia and reperfusion. (3) IR + PG: rats underwent the same IR protocol as the IR group and were injected with PG (16 mg/kg, i.p.) before both ischemia and reperfusion. After reperfusion, rats were sacrificed, and lung tissues were taken out for histopathologic and biochemical analyses. Results: In IR + PG group, tissue levels of malondialdehyde and nitric oxide decreased significantly compared with the IR group (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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