Spatio-temporal expression of cysteinyl leukotriene receptor-2 mRNA in rat brain after focal cerebral ischemia
| Autor: | Wei-Ping Zhang, Meng-Ling Wang, Er-Qing Wei, Li-Sheng Chu, Guo-liang Yu, Fang Peng, Yu Zhou, San-Hua Fang |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Receptor expression Population Central nervous system Ischemia Brain Ischemia Rats Sprague-Dawley Internal medicine medicine Animals RNA Messenger education Receptor Receptors Leukotriene education.field_of_study Reverse Transcriptase Polymerase Chain Reaction business.industry General Neuroscience Brain Membrane Proteins medicine.disease Rats medicine.anatomical_structure Endocrinology Cysteinyl leukotriene receptor 2 Gene Expression Regulation Reperfusion Neuron business Neuroscience Astrocyte |
| Zdroj: | Neuroscience Letters. 412:78-83 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2006.10.065 |
| Popis: | Cysteinyl leukotrienes (CysLTs) induce inflammatory responses mediated by activating CysLT 1 and CysLT 2 receptors. We have recently reported that CysLT 1 receptor expression is increased in rat brain after focal cerebral ischemia and the increased expression is spatio-temporally related to acute neuronal injury and late astrocyte proliferation. Here we report spatio-temporal expression of CysLT 2 receptor mRNA in rat brain after focal cerebral ischemia induced by 30 min of middle cerebral artery occlusion. We found that the neuron density was gradually decreased or disappeared in the ischemic core and boundary zone during 14 days after reperfusion, and the astrocyte population in the boundary zone was increased 3–14 days after reperfusion. In the ischemic core, the expression of CysLT 2 receptor mRNA was increased at 6, 12 and 24 h and then recovered at 3, 7 and 14 days after reperfusion. In the boundary zone, the expression was significantly increased 3, 7 and 14 days after reperfusion. The results suggest that CysLT 2 receptor may be related to the acute neuronal injury and late astrocyte proliferation in the ischemic brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect