The gut microbiome modulates gut–brain axis glycerophospholipid metabolism in a region-specific manner in a nonhuman primate model of depression
| Autor: | Weiwei Liang, Ma-Li Wong, Hanping Zhang, Peng Zheng, Yu Huang, Jiajia Duan, Xunmin Tan, Bangmin Yin, Peng Xie, Seth W. Perry, Yifan Li, Jing Wu, Tingjia Chai, Julio Licinio |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gut–brain axis Glycerophospholipids Hippocampal formation Biology Article 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Animals Molecular Biology Gene Depression (differential diagnoses) Depression Gastrointestinal Microbiome Brain Glycerophospholipid metabolism Sphingolipid Cell biology Macaca fascicularis Psychiatry and Mental health 030104 developmental biology Female 030217 neurology & neurosurgery Function (biology) |
| Zdroj: | Mol Psychiatry |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/s41380-020-0744-2 |
| Popis: | Emerging research demonstrates that microbiota-gut–brain (MGB) axis changes are associated with depression onset, but the mechanisms underlying this observation remain largely unknown. The gut microbiome of nonhuman primates is highly similar to that of humans, and some subordinate monkeys naturally display depressive-like behaviors, making them an ideal model for studying these phenomena. Here, we characterized microbial composition and function, and gut–brain metabolic signatures, in female cynomolgus macaque (Macaca fascicularis) displaying naturally occurring depressive-like behaviors. We found that both microbial and metabolic signatures of depressive-like macaques were significantly different from those of controls. The depressive-like monkeys had characteristic disturbances of the phylum Firmicutes. In addition, the depressive-like macaques were characterized by changes in three microbial and four metabolic weighted gene correlation network analysis (WGCNA) clusters of the MGB axis, which were consistently enriched in fatty acyl, sphingolipid, and glycerophospholipid metabolism. These microbial and metabolic modules were significantly correlated with various depressive-like behaviors, thus reinforcing MGB axis perturbations as potential mediators of depression onset. These differential brain metabolites were mainly mapped into the hippocampal glycerophospholipid metabolism in a region-specific manner. Together, these findings provide new microbial and metabolic frameworks for understanding the MGB axisʼ role in depression, and suggesting that the gut microbiome may participate in the onset of depressive-like behaviors by modulating peripheral and central glycerophospholipid metabolism. |
| Databáze: | OpenAIRE |
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