Cytogenetic abnormalities in childhood acute lymphoblastic leukemia
| Autor: | P. M. Ellis, P. D. Micallef-Eynaud, E. Grace, O. B. Eden |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Oncology
Male medicine.medical_specialty Pathology Pseudodiploid Leukocyte Count Bone Marrow Internal medicine Acute lymphocytic leukemia medicine Humans Child Childhood Acute Lymphoblastic Leukemia business.industry Incidence (epidemiology) Cytogenetics Karyotype Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Prognosis Diploidy Chromosome Banding Child Preschool Karyotyping Pediatrics Perinatology and Child Health Cohort Female Hyperdiploidy business |
| Zdroj: | Pediatric hematology and oncology. 10(1) |
| ISSN: | 0888-0018 |
| Popis: | A review of the cytogenetic analyses of a cohort of unselected patients with acute lymphoblastic leukemia from a single institution (1981-1989) confirmed hyperdiploidy > 50 as a favorable prognostic feature and pseudodiploidy, especially with chromosomal rearrangements, as an adverse one. In the early years of the study, a high incidence of diploid karyotype was identified, but with time (better banding and more intensive search) the incidence has fallen to 7.7%. Many such patients have been shown to be pseudodiploid. Molecular genetic techniques are increasingly identifying clonal abnormalities. |
| Databáze: | OpenAIRE |
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