Thigh and abdominal adipose tissue depot associations with testosterone levels in postmenopausal females

Autor: Karin Zwygart, Henry Hugues, Francesca Amati, Sonia Conde Alonso, Andrew A. Dwyer, Elvis A. Carnero, Lorena Correas‐Gomez, Daniel Bardy, Didier Hans, Emmanuel Kwaku Ofori
Rok vydání: 2019
Předmět:
Zdroj: Clinical endocrinology, vol. 90, no. 3, pp. 433-439
ISSN: 0300-0664
DOI: 10.1111/cen.13921
Popis: Research findings on the relationship between serum androgens and adipose tissue in older females are inconsistent. We aimed to clarify the relationship using state-of-the-art techniques to evaluate associations between body fat distribution and plasma testosterone (T) levels in older postmenopausal women. Observational, cross-sectional study of healthy, community dwelling postmenopausal women. Postmenopausal women (60-80 years old) were included in this study. Overall body composition was evaluated by dual-energy X-ray absorptiometry. Abdominal and thigh fat depots were measured by magnetic resonance imaging. Circulating T concentrations were analysed by liquid chromatography-tandem mass spectrometry. Thirty-five women (66.6 ± 0.8 years) participated in this study. T levels were positively associated with clinical proxy measures of adiposity including weight (ρ = 0.39), BMI (ρ = 0.43) and waist circumference (ρ = 0.39) (all P < 0.05). Fat mass and % body fat were correlated with T levels (ρ = 0.42 and 0.38 respectively, both P < 0.05). T correlated with overall and superficial abdominal fat (ρ = 0.34 and 0.37 respectively, both P < 0.05) but not with visceral adipose tissue. T increased with greater thigh fat (ρ = 0.49, P < 0.05) in both superficial and deep depots (ρ = 0.50 and 0.35 respectively, both P < 0.05). Our results suggest that postmenopausal women with higher circulating T levels have both higher regional and overall body adiposity. These findings underscore the sexual dimorphism in the relationship between serum androgen levels and adiposity.
Databáze: OpenAIRE
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